Gualano Maria R, Gili Renata, Scaioli Giacomo, Bert Fabrizio, Siliquini Roberta
Department of Public Health, University of Turin, Turin, Italy.
Pharmacoepidemiol Drug Saf. 2015 Jan;24(1):2-10. doi: 10.1002/pds.3716. Epub 2014 Sep 24.
Nowadays, the development of antibiotic resistance represents one of the most important issues of the global public health. The incorrect use of antimicrobial drugs is recognized as one of the leading causes of antibiotic resistance. Therefore, a better understanding of the existing pieces of evidence pertaining knowledge and attitudes about antibiotic and antibiotic resistance in the general population worldwide is advisable.
A systematic review and proportion meta-analyses were performed through PubMed and Scopus scientific databases. Cross-sectional studies published from January 2000 to November 2013 and investigating knowledge about antibiotic use and antibiotic resistance were included.
Overall, 26 studies have been selected for the systematic review, and 24 of these were included in the meta-analyses. A lack of knowledge about antibiotics was detected. In particular, 33.7% (95%CI 25.2-42.8) of the sample did not know that antibiotics can treat bacterial infections, and 53.9% (95%CI 41.6-66.0) of them did not know that antibiotics are not useful against viruses. Besides, although 59.4% (95%CI 45.7-72.4) of the sample was aware of antibiotic resistance, 26.9% (95%CI 16.6-38.7) of them did not know that misuse of antibiotics can lead to this problem. Finally, 47.1% (95%CI 36.1-58.2) of the subjects stop taking antibiotics when they start feeling better.
It would be necessary to strengthen educational initiatives in the community and to push physicians to correctly inform patients in order to make them aware of the importance of a correct behavior concerning antibiotic consumption.
如今，抗生素耐药性的发展是全球公共卫生领域最重要的问题之一。抗菌药物的不当使用被认为是抗生素耐药性的主要原因之一。因此，最好能更好地了解全球普通人群中有关抗生素及抗生素耐药性的现有知识和态度方面的证据。
通过PubMed和Scopus科学数据库进行系统综述和比例荟萃分析。纳入2000年1月至2013年11月发表的、调查抗生素使用知识和抗生素耐药性的横断面研究。
总体而言，26项研究被选入系统综述，其中24项纳入荟萃分析。发现存在抗生素知识缺乏的情况。具体而言，33.7%（95%置信区间25.2 - 42.8）的样本不知道抗生素可治疗细菌感染，53.9%（95%置信区间41.6 - 66.0）的样本不知道抗生素对病毒无效。此外，虽然59.4%（95%置信区间45.7 - 72.4）的样本知晓抗生素耐药性，但26.9%（95%置信区间16.6 - 38.7）的样本不知道抗生素的滥用会导致这一问题。最后，47.1%（95%置信区间36.1 - 58.2）的受试者在感觉好转时就停止服用抗生素。
有必要加强社区教育举措，并促使医生正确告知患者，以使他们意识到在抗生素使用方面正确行为的重要性。
