正电子发射断层扫描及正电子发射断层扫描-计算机断层扫描在检测（131）I全身扫描结果为阴性的分化型甲状腺癌复发中的准确性：一项荟萃分析。
Accuracy of positron emission tomography and positron emission tomography-CT in the detection of differentiated thyroid cancer recurrence with negative (131) I whole-body scan results: A meta-analysis.
作者信息
Caetano Rosângela, Bastos Cláudia Regina Garcia, de Oliveira Ione Ayala Gualandi, da Silva Rondineli Mendes, Fortes Clarisse Pereira Dias Drumond, Pepe Vera Lucia Edais, Reis Lenice Gnocchi, Braga José Ueleres
机构信息
Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.
Regional Council of Pharmacy of the State of Rio de Janeiro (Conselho Regional de Farmácia do Estado do Rio de Janeiro - CRF-RJ), Rio de Janeiro, Brazil.
出版信息
Head Neck. 2016 Feb;38(2):316-27. doi: 10.1002/hed.23881. Epub 2015 May 26.
BACKGROUND
The purpose of this review was to present a meta-analysis aimed to evaluate the accuracy of positron emission tomography (PET) and PET-CT for detecting recurrence of differentiated thyroid carcinoma (DTC) not identified by (131) I whole-body scintigraphy.
METHODS
MEDLINE, EMBASE, LILACS, and Cochrane databases were searched for studies published between January 1985 and March 2012. Systematic methods were used to select and evaluate the quality of studies. Pooled sensitivity and specificity for conventional PET and PET-CT was estimated using random effects model.
RESULTS
Twenty studies were included in the systematic review; the data of 18 studies were used in the meta-analysis. The combined sensitivity and specificity for conventional PET were both found to be 84%; for PET-CT, they were 93% and 81%, respectively. The overall accuracies were 91% and 93%, respectively.
CONCLUSION
(18) Fluorodeoxyglucose (FDG)-PET and PET-CT are highly accurate diagnostics tools for DTC recurrence in patients who present a negative whole-body scintigraphy and could impact the clinical and therapeutic management of DTC.
背景
本综述的目的是进行一项荟萃分析，旨在评估正电子发射断层扫描（PET）和PET-CT在检测经（131）I全身闪烁扫描未发现的分化型甲状腺癌（DTC）复发方面的准确性。
方法
检索MEDLINE、EMBASE、LILACS和Cochrane数据库中1985年1月至2012年3月发表的研究。采用系统方法选择和评估研究质量。使用随机效应模型估计传统PET和PET-CT的合并敏感性和特异性。
结果
系统评价纳入20项研究；荟萃分析使用了18项研究的数据。发现传统PET的合并敏感性和特异性均为84%；PET-CT的合并敏感性和特异性分别为93%和81%。总体准确率分别为91%和93%。
结论
（18）氟脱氧葡萄糖（FDG）-PET和PET-CT是全身闪烁扫描呈阴性的DTC患者复发的高度准确诊断工具，可能会影响DTC的临床和治疗管理。
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