在手性螺旋聚合物骨架上生成的手性钯环催化剂，用于 1,4-环氧-1,4-二氢萘的不对称芳基环开环反应。
Chiral palladacycle catalysts generated on a single-handed helical polymer skeleton for asymmetric arylative ring opening of 1,4-epoxy-1,4-dihydronaphthalene.
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510 (Japan).
出版信息
Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12785-8. doi: 10.1002/anie.201407358. Epub 2014 Sep 22.
Post-polymerization CH activation of poly(quinoxaline-2,3-diyl)-based helically chiral phosphine ligands (PQXphos) with palladium(II) acetate afforded chiral phosphapalladacycles quantitatively. In situ generated palladacycles exhibited enantioselectivities up to 94 % ee in the palladium-catalyzed asymmetric ring-opening arylation of 1,4-epoxy-1,4-dihydronaphthalenes with arylboronic acids.
聚（喹喔啉-2,3-二基）-手性膦配体（PQXphos）经聚合后 CH 活化，与醋酸钯反应定量生成手性膦钯配合物。在钯催化的 1,4-环氧-1,4-二氢萘与芳基硼酸的不对称开环芳基化反应中，原位生成的钯配合物表现出高达 94%ee 的对映选择性。
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