Tian Yulin, Wang Xiaojian, Xiao Qiong, Sun Chenbin, Yin Dali
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and ‡Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, P. R. China.
J Org Chem. 2014 Oct 17;79(20):9678-85. doi: 10.1021/jo501824z. Epub 2014 Oct 2.
A facile and versatile synthesis of dihydrobenzoheterocycles via Al(OTf)3-mediated cascade cyclization and ionic hydrogenation has been developed. The reaction is applicable to a wide range of substrates with various functional groups to afford the corresponding products in good yields.
