[甲状旁腺激素样激素在胚胎发育过程中的作用]

[Role of parathyroid hormone-like hormone during embryonic development].

作者信息

Li Yuanyuan, Guo Lei, Lu Shengsheng, Han Zhiming

机构信息

College of Animal Science and Technology, Guangxi University, Nanning 530004, China; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Yi Chuan. 2014 Sep;36(9):871-8. doi: 10.3724/SP.J.1005.2014.0871.

DOI:10.3724/SP.J.1005.2014.0871

PMID:25252304

Abstract

Parathyroid hormone-like hormone (PTHLH), also known as parathyroid hormone-related protein (PTHrP), was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcaemia in malignancies. Subsequent studies demonstrated that PTHLH has multiple physiological functions in many fetal and adult tissues, including the regulation of morphogenesis, cell proliferation and differentiation, and transplacental calcium transport. This review focuses on the biological characteristics of PTHLH and its function during embryonic development. The signaling pathway and potential mechanism involved are further discussed.

摘要

甲状旁腺激素样激素（PTHLH），也称为甲状旁腺激素相关蛋白（PTHrP），最初被鉴定为一种甲状旁腺激素（PTH）样因子，负责恶性肿瘤中的体液性高钙血症。随后的研究表明，PTHLH在许多胎儿和成人组织中具有多种生理功能，包括形态发生、细胞增殖和分化的调节以及跨胎盘钙转运。本综述重点关注PTHLH的生物学特性及其在胚胎发育过程中的功能。进一步讨论了其涉及的信号通路和潜在机制。