Haider Imran, Siddiqui Muhammad, Naji Wisam, Sheikh Maria, Waqar Ayesha
J Pak Med Assoc. 2014 Jun;64(6):711-3.
Penile gangrene is a rare disease. It represents a poor prognostic sign in end stage renal disease (ESRD) patients and an indicator of metastatic vascular calcification. Pathogenesis of this life threatening condition is not clearly understood and treatment is also controversial. We describe the case of a 61-year-old man known to have diabetes mellitus, chronic renal failure on haemodialysis, who was complaining of worsening groin pain for 4 weeks. On examination dry gangrene of glans penis was noted. Cultures from the penis showed multiple organisms. Computed tomography (CT) showed diffuse calcification of external and internal iliac arteries. Later, he developed caciphylaxis of right anterior thigh. His overall condition did not improve in spite of adequate antibiotics and he was shifted to intensive care unit (ICU) where he required high doses of vasopressors. Clinically he kept deteriorating and passed away due to septic shock.
阴茎坏疽是一种罕见疾病。它在终末期肾病（ESRD）患者中代表预后不良的体征，也是转移性血管钙化的一个指标。这种危及生命状况的发病机制尚不清楚，治疗也存在争议。我们描述了一名61岁男性的病例，该患者患有糖尿病、接受血液透析的慢性肾衰竭，他主诉腹股沟疼痛加重4周。检查发现阴茎头干性坏疽。阴茎培养显示有多种微生物。计算机断层扫描（CT）显示髂外动脉和髂内动脉弥漫性钙化。后来，他右大腿前部发生了钙化防御。尽管使用了足够的抗生素，他的整体状况仍未改善，被转入重症监护病房（ICU），在那里他需要高剂量的血管升压药。临床上他的病情持续恶化，最终因感染性休克去世。
