Ziaian Bizhan, Hosseinzadeh Massood, Nikravesh Behroz, Roshanravan Reza, Rahimikazerooni Salar, Safarpour Ali Reza, Moslemi Sam
J Pak Med Assoc. 2014 Aug;64(8):907-10.
To evaluate the outcomes of jejunal serosal patch and jejunal pedicled flap procedures for the repair of duodenal injuries.
The experimental animal-model study was conducted at Shiraz University of Medical Sciences, Iran, in February 2013. Ten mixed-breed male dogs were selected and randomly divided into groups A and B. After general anaesthesia, a large duodenal defect was created in all animals. The defect was repaired with jejunal pedicled flap in group A and jejunal serosal patch in group B. Microscopic healing was scored according to epithelialisation, collagenisation, inflammation, ulcer and necrosis of samples. Kolmogorov-Smirnov and independent t-test were used to indicate normal distributions of data and statistical differences between the two groups respectively.
The weight of the animals ranged between 23 and 37 kg and the age range was 12-16 months. All dogs survived the procedures. Anastomotic leakage, intra-abdominal abscess or intestinal obstructions were not detected in gross examination. Healing score was significantly higher in the group A than group B (p < 0.011). However, in terms of surgical findings, no significant difference was detected between the groups (p > 0.05).
Applying jejunal pedicled flap for repairing large duodenal defects would lead to better histologic outcomes compared to jejunal serosal patch in dogs.
评估空肠浆膜补片和空肠带蒂皮瓣修复十二指肠损伤的效果。
2013年2月在伊朗设拉子医科大学进行了实验动物模型研究。选取10只杂种雄性犬，随机分为A组和B组。全身麻醉后，在所有动物身上制造一个大的十二指肠缺损。A组用空肠带蒂皮瓣修复缺损，B组用空肠浆膜补片修复。根据样本的上皮化、胶原化、炎症、溃疡和坏死情况对微观愈合进行评分。分别用柯尔莫哥洛夫-斯米尔诺夫检验和独立t检验来表明数据的正态分布以及两组之间的统计学差异。
动物体重在23至37千克之间，年龄在12至16个月之间。所有犬均在手术后存活。大体检查未发现吻合口漏、腹腔脓肿或肠梗阻。A组的愈合评分显著高于B组（p < 0.011）。然而，就手术结果而言，两组之间未发现显著差异（p > 0.05）。
与空肠浆膜补片相比，应用空肠带蒂皮瓣修复犬的大十二指肠缺损可获得更好的组织学结果。
