Sunahara Hiroshi, Fujii Yoko, Sugimoto Keisuke, Aoki Takuma, Sugahara Gou, Shirota Kinji
Laboratory of Surgery 1, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
J Vet Med Sci. 2015 Jan;77(1):95-9. doi: 10.1292/jvms.14-0242. Epub 2014 Sep 23.
A two-month-old female Chihuahua was diagnosed as severe pulmonary valvular stenosis (PS). Although balloon valvuloplasty (BV) was successfully performed, restenosis was observed 19 months after the procedure. Euthanasia was chosen due to low output syndrome during the surgical repair attempted when the dog was 5 years old. Postmortem examination revealed markedly thickened pulmonary valve due to the increase of extracellular matrix which might be produced by increased α smooth muscle actin-positive myofibroblasts. The thickening of the valve was associated with restriction of the valve's motion, resulting in restenosis in the present case. This is the first case report documented histopathological and immunohistochemical findings of the restenotic pulmonary valve in dogs with PS after BV.
一只两个月大的雌性吉娃娃犬被诊断为重度肺动脉瓣狭窄（PS）。尽管成功进行了球囊瓣膜成形术（BV），但术后19个月观察到再狭窄。这只狗5岁时尝试进行手术修复，因低输出量综合征而选择实施安乐死。尸检显示，由于细胞外基质增加，肺动脉瓣明显增厚，这可能是由α平滑肌肌动蛋白阳性肌成纤维细胞增多所致。瓣膜增厚与瓣膜活动受限有关，导致了本例中的再狭窄。这是第一例记录了球囊瓣膜成形术后患有肺动脉瓣狭窄的犬再狭窄肺动脉瓣组织病理学和免疫组化结果的病例报告。
