Park Jong Kyu, Huh Kyu Chan, Shin Cheol Min, Lee Hyuk, Yoon Young Hoon, Song Kyung Ho, Min Byung Hoon, Choi Kee Don
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Konyang University College of Medicine, Daejeon, Korea.
Korean J Gastroenterol. 2014 Sep 25;64(3):133-41. doi: 10.4166/kjg.2014.64.3.133.
Functional dyspepsia is one of the most common gastrointestinal disorders encountered in clinical practice. Functional dyspepsia is currently defined by Rome III criteria as the chronic dyspeptic symptoms (postprandial fullness, early satiety, epigastric pain or burning) in the absence of underling structural or metabolic disease that readily explain the symptoms. According to the Rome III consensus, functional dyspepsia can be subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Although the Rome III criteria have been published more than 8 years ago, not much effort has been put into validating these criteria and direct scientific evidence supporting the validity of the subdividing functional dyspepsia into PDS and EPS are lacking. This article is intended to review the validity of the Rome III criteria on the subdivisions of functional dyspepsia, i.e. PDS and EPS. The impact of sleep disorder, Helicobacter pylori-associated dyspepsia, and the emerging drug therapies in functional dyspepsia will also be discussed in this article.
功能性消化不良是临床实践中最常见的胃肠疾病之一。目前，罗马Ⅲ标准将功能性消化不良定义为存在慢性消化不良症状（餐后饱胀、早饱、上腹部疼痛或烧灼感），但没有能够轻易解释这些症状的潜在结构性或代谢性疾病。根据罗马Ⅲ共识，功能性消化不良可细分为餐后不适综合征（PDS）和上腹痛综合征（EPS）。尽管罗马Ⅲ标准在8年多以前就已发布，但在验证这些标准方面投入的精力不多，且缺乏支持将功能性消化不良细分为PDS和EPS有效性的直接科学证据。本文旨在综述罗马Ⅲ标准在功能性消化不良细分（即PDS和EPS）方面的有效性。本文还将讨论睡眠障碍、幽门螺杆菌相关性消化不良以及功能性消化不良新兴药物疗法的影响。
