Department of Family Medicine, Warsaw Medical University, 1A Banacha St., Block F, 02-097, Warsaw, Poland,
Adv Exp Med Biol. 2015;835:45-51. doi: 10.1007/5584_2014_32.
Current and detailed knowledge of antibiotic use is essential in order to implement strategies for reducing the overuse of antibiotics. The objective of our study was to determine the effectiveness of the implementation of the hospital antibiotic policy (HAP) by assessing antibiotic consumption in the Special Neonatal Care Unit (SNCU) in Warsaw, Poland, before and after this intervention. Antibiotic use was calculated in daily defined doses (DDDs) per 100 patient-days and DDDs per 100 admissions. The antibiotics were ranked by volume of DDDs and the number of antibiotics, which accounted for 90 % and 100 % of the total volume, respectively: DU90% and DU100% (where DU stands for drug use). Total antibiotic consumption increased slightly after the introduction of the HAP: the total DDDS was 707.87 and 753.12 in 2011 and 2012, while the number of DDDs/100 admissions was 352.17 and 369.12 in 2011 and 2012, respectively. After the introduction of the HAP, an increase in ampicillin and aminoglycoside use was observed, along with a reduction in the DU100% and DU90% rates (15 vs. 9 and 4 vs. 3, respectively). The introduction of the HAP resulted in changes in antibiotic consumption patterns, but the general antibiotic consumption density remained the same.
为了实施减少抗生素过度使用的策略，掌握当前和详细的抗生素使用知识至关重要。我们的研究目的是通过评估波兰华沙特殊新生儿护理病房（SNCU）在实施医院抗生素政策（HAP）前后的抗生素使用情况，来确定该政策的实施效果。抗生素使用量以每 100 个患者日的每日限定剂量（DDD）和每 100 个入院患者的 DDD 来计算。根据 DDD 量和抗生素种类对抗生素进行排名，分别占总量的 90%和 100%：DU90%和 DU100%（其中 DU 代表药物使用）。HAP 实施后，抗生素总用量略有增加：2011 年和 2012 年的总 DDD 分别为 707.87 和 753.12，而每 100 个入院患者的 DDD 分别为 352.17 和 369.12。HAP 实施后，观察到氨苄西林和氨基糖苷类药物的使用增加，同时 DU100%和 DU90%的比例降低（分别为 15 比 9 和 4 比 3）。HAP 的实施导致抗生素使用模式发生变化，但总体抗生素使用密度保持不变。
