Dananché Cédric, Cassier Pierre, Sautour Marc, Gautheron Nadine, Wegrzyn Julien, Perraud Michel, Bienvenu Anne-Lise, Nicolle Marie-Christine, Boibieux André, Vanhems Philippe
Infection Control Department and Environmental Analysis Laboratory, Service Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5 place d'Arsonval, 69437, Lyon Cedex 03, France,
Mycopathologia. 2015 Feb;179(1-2):135-40. doi: 10.1007/s11046-014-9817-6. Epub 2014 Sep 25.
Recent literature has shown the growing importance of opportunistic fungal infections due to Fusarium spp. However, disseminated fusariosis remains rare in patients without neutropenia. We report a case of fungaemia in a 78-year-old French woman without definite immunodeficiency. Fusarium proliferatum grew from both central and peripheral blood cultures. Fever was the only clinical sign of the infection. An appropriate antifungal therapy with voriconazole led to the recovery of the patient. An environmental investigation was undertaken but failed to find a reservoir of Fusarium spores. A contaminated central venous catheter might have been the source of fungaemia.
近期文献表明，由镰刀菌属引起的机会性真菌感染愈发重要。然而，在无中性粒细胞减少症的患者中，播散性镰刀菌病仍然罕见。我们报告一例78岁法国女性的真菌血症病例，该患者无明确免疫缺陷。从中心血培养和外周血培养中均分离出层出镰刀菌。发热是该感染的唯一临床症状。使用伏立康唑进行适当的抗真菌治疗使患者康复。进行了环境调查，但未发现镰刀菌孢子的储存源。受污染的中心静脉导管可能是真菌血症的来源。
