Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen
Neuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen.
Psychol Sci. 2014 Nov;25(11):2058-66. doi: 10.1177/0956797614548877. Epub 2014 Sep 24.
The alleged association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and amygdala activation forms a cornerstone of the common view that carrying the short allele of this polymorphism is a potential risk factor for affective disorders. The authors of a recent meta-analysis showed that this association is statistically significant (Hedges's g = 0.35) but warned that estimates might be distorted because of publication bias. Here, we report a replication study of this relationship in 120 participants. We failed to find an association of 5-HTTLPR variation with amygdala activation during a widely used emotional-face-matching paradigm. Moreover, when we conducted a meta-analysis that included unpublished studies and data from the current study, the pooled meta-analytic effect size was no longer significant (g = 0.20, p = .06). These findings cast doubt on previously reported substantial effects, suggesting that the 5-HTTLPR-amygdala association is either much smaller than previously thought, conditional on other factors, or nonexistent.
被认为与血清素转运体相关的多态性区域（5-HTTLPR）和杏仁核激活之间的关联构成了这样一种普遍观点的基石，即携带这种多态性的短等位基因是情感障碍的潜在风险因素。最近一项荟萃分析的作者表明，这种关联在统计学上是显著的（Hedges 的 g = 0.35），但警告说由于发表偏倚，估计可能会受到扭曲。在这里，我们报告了对 120 名参与者的这种关系的复制研究。我们未能发现 5-HTTLPR 变异与在广泛使用的情绪面孔匹配范式期间杏仁核激活之间的关联。此外，当我们进行包括未发表研究和当前研究数据的荟萃分析时，汇总的荟萃分析效应大小不再显著（g = 0.20，p =.06）。这些发现对先前报道的大量影响提出了质疑，表明 5-HTTLPR-杏仁核关联要么比以前认为的小得多，要么在其他因素的条件下不存在。
