Aizawa T, Ogasawara K, Nakamura F, Hirosaka A, Sakuma T, Nagashima K, Kato K
Cardiovascular Institute Hospital, Tokyo, Japan.
Am J Cardiol. 1989 Jun 20;63(21):75J-79J. doi: 10.1016/0002-9149(89)90210-5.
In patients in whom dynamic coronary obstruction plays a predominant role in the pathogenesis of angina pectoris, dilatation of large coronary arteries and relief of coronary spasm account for the main mechanism of action of antianginal drugs. In this study, the acute vasodilating effects of nicorandil, a newly developed antianginal drug, were assessed in 10 patients who had spontaneous and ergonovine-evoked coronary spasms. The prompt, complete relief of both spontaneous and evoked coronary spasms was obtained in all of 10 patients with nicorandil. The coronary spasmolytic effect of nicorandil in the present series is thus considered to be beneficial to the treatment of coronary spasm.
在动态冠状动脉阻塞在心绞痛发病机制中起主要作用的患者中，大冠状动脉扩张和冠状动脉痉挛缓解是抗心绞痛药物的主要作用机制。在本研究中，对10例有自发性和麦角新碱诱发冠状动脉痉挛的患者评估了新开发的抗心绞痛药物尼可地尔的急性血管舒张作用。10例患者使用尼可地尔后，自发性和诱发的冠状动脉痉挛均迅速、完全缓解。因此，本系列研究中尼可地尔的冠状动脉解痉作用被认为对冠状动脉痉挛的治疗有益。
