Xiao Qian, Liao Linda, Matthews Charles E, Chow Wong-Ho, Davis Faith, Schwartz Kendra, Purdue Mark, Hofmann Jonathan N, Colt Joanne
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
BMC Cancer. 2014 Sep 24;14:707. doi: 10.1186/1471-2407-14-707.
Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated this relationship in the black population.
We examined the association between self-reported physical activity at different ages and risk of RCC in a population based case-control study of 1217 cases (361 black, 856 white) and 1235 controls (523 black, 712 white) frequency-matched on age, race, and gender. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression.
Among whites, increased risks of RCC were observed among participants reporting low levels of transportation-related activity in their 20's (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.42 (1.10, 1.83)) and leisure time activity in their 50's (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.49 (1.00, 2.20)). We found no association between physical activity and RCC risk among blacks.
Our results suggest that physical activity may be inversely associated with RCC risk in whites, but there was no evidence of such an association in blacks. As this is the first study evaluating the effect of physical activity on RCC risk among blacks, further investigations are needed to clarify the relationship in this population.
肾细胞癌（RCC）在黑人中的发病率高于白人。身体活动可能会影响肾细胞癌的风险，但证据并不一致。此前尚无研究在黑人人群中调查这种关系。
在一项基于人群的病例对照研究中，我们纳入了1217例患者（361例黑人，856例白人）和1235例对照（523例黑人，712例白人），这些患者和对照在年龄、种族和性别上进行了频率匹配，以研究不同年龄段自我报告的身体活动与RCC风险之间的关联。使用无条件逻辑回归估计多变量调整后的比值比（OR）和95%置信区间（CI）。
在白人中，报告20多岁时交通相关活动水平较低的参与者（OR <1小时/周与>7小时/周相比（95%CI）：1.42（1.10，1.83））以及50多岁时休闲时间活动水平较低的参与者（OR <1小时/周与>7小时/周相比（95%CI）：1.49（1.00，2.20））患RCC的风险增加。我们发现黑人的身体活动与RCC风险之间没有关联。
我们的结果表明，身体活动可能与白人的RCC风险呈负相关，但在黑人中没有这种关联的证据。由于这是第一项评估身体活动对黑人RCC风险影响的研究，需要进一步调查以阐明该人群中的关系。
