Kim Do-Hyung, Kwon Oh-Young, Jung Suck-Won, Jeong Heejeong, Son Seongnam, Kim Soo-Kyoung, Kang Heeyoung, Park Ki-Jong, Choi Nack-Cheon, Lim ByeongHoon
Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
Clin EEG Neurosci. 2016 Jul;47(3):235-42. doi: 10.1177/1550059414548859. Epub 2014 Sep 23.
Although many schizencephaly patients suffer from epilepsy, the relationship between schizencephalic lesions and epileptic foci remains unclear. Previous studies have shown that schizencephalic lesions may be associated with, rather than contain, epileptogenic zones. Thus, the purpose of this study was to investigate the current source distribution (CSD) of epileptiform discharges in schizencephalic patients and to correlate this activity with existing structural lesions. A consecutive series of 30 schizencephalic patients who were diagnosed using brain magnetic resonance imaging (MRI) were selected retrospectively and prospectively. Of the original 30 subjects selected, 13 had epilepsy, and 6 of these patients exhibited schizencephaly, epilepsy, and interictal spikes on electroencephalograms (EEG) and were enrolled in the present study investigating the current source analysis of interictal spikes. The CSDs of the initial rising phases and the peak points of the interictal spikes were obtained using standardized low-resolution brain electromagnetic tomography (LORETA). Five patients exhibited a single focus of interictal spikes, while 1 patient showed 2 foci. Relative to the structural brain lesions, 5 patients displayed extrinsically localized CSDs, while 1 patient showed a partially intrinsically localized CSD. The present findings demonstrate that the CSDs of interictal spikes in schizencephalic patients are in general anatomically distinct from the cerebral schizencephalic lesions and that these lesions may display an extrinsic epileptogenicity.
尽管许多无脑回畸形患者患有癫痫，但无脑回畸形病变与癫痫灶之间的关系仍不清楚。先前的研究表明，无脑回畸形病变可能与致痫区相关，而非包含致痫区。因此，本研究的目的是调查无脑回畸形患者癫痫样放电的电流源分布（CSD），并将这种活动与现有的结构病变相关联。回顾性和前瞻性地选取了连续30例经脑磁共振成像（MRI）诊断的无脑回畸形患者。在最初选取的30名受试者中，13名患有癫痫，其中6名患者在脑电图（EEG）上表现出无脑回畸形、癫痫和发作间期棘波，并被纳入本研究，以调查发作间期棘波的电流源分析。使用标准化低分辨率脑电磁断层扫描（LORETA）获得发作间期棘波初始上升期和峰值点的CSD。5名患者表现为单个发作间期棘波灶，而1名患者表现为2个病灶。相对于脑部结构病变，5名患者表现为外在局限性CSD，而l名患者表现为部分内在局限性CSD。本研究结果表明，无脑回畸形患者发作间期棘波的CSD在解剖学上通常与脑无脑回畸形病变不同，并且这些病变可能表现出外在致痫性。
