Madrid-Miller Alejandra, Chávez-Sánchez Luis, Careaga-Reyna Guillermo, Borrayo-Sánchez Gabriela, Chávez-Rueda Karina, Montoya-Guerrero Silvestre Armando, Abundes Velazco Arturo, Ledesma-Velasco Mariano, Legorreta-Haquet María Victoria, Blanco-Favela Francisco
Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330, Col, Doctores, CP: 06720 México City, México.
BMC Res Notes. 2014 Sep 24;7:669. doi: 10.1186/1756-0500-7-669.
Pro-inflammatory molecules and low-density lipoproteins play essential roles in the atherosclerosis. The aim of our study was to establish an association among the cytokines secreted by peripheral blood mononuclear cells and the serum concentration in patients with unstable angina and coronary outward remodeling before and after percutaneous coronary intervention. The clinical and coronary responses were evaluated 6 months after the procedure.
Twenty-two patients with unstable angina were evaluated prior to after percutaneous coronary intervention and 6 months after procedure by coronary intravascular ultrasound. Eleven of the patients had recurrent angina, while 9 presented restenosis and an increase in the percentage of total plaque area. These 11 patients displayed higher levels of C-reactive protein than those without coronary events (1.27 vs. 0.43 mg/dl, respectively; p = 0.029) and a tendency to increase levels of interleukin (IL)-8 and transforming growth factor-β1, but lower levels of IL-10 (52.09 vs. 141.5 pg/ml, respectively; p = 0.035). Activated peripheral blood mononuclear cells from patients with restenosis presented higher levels of proliferation, CD86 expression and higher IL-1, and increased IL-10 compared to those in patients without restenosis.
Patients with unstable angina and coronary outward remodeling who displayed a pro-inflammatory response experienced recurrent coronary events and an increased percentage of total plaque area. In contrast, better outcomes were observed in patients with anti-inflammatory responses. This response could be secondary to low-density lipoproteins.
促炎分子和低密度脂蛋白在动脉粥样硬化中起重要作用。我们研究的目的是确定不稳定型心绞痛和经皮冠状动脉介入治疗前后冠状动脉向外重塑患者外周血单个核细胞分泌的细胞因子与血清浓度之间的关联。术后6个月评估临床和冠状动脉反应。
22例不稳定型心绞痛患者在经皮冠状动脉介入治疗前后及术后6个月接受冠状动脉血管内超声评估。其中11例患者复发心绞痛，9例出现再狭窄且总斑块面积百分比增加。这11例患者的C反应蛋白水平高于无冠状动脉事件的患者（分别为1.27 vs. 0.43 mg/dl；p = 0.029），白细胞介素（IL）-8和转化生长因子-β1水平有升高趋势，但IL-10水平较低（分别为52.09 vs. 141.5 pg/ml；p = 0.035）。与无再狭窄患者相比，再狭窄患者活化的外周血单个核细胞增殖水平更高、CD86表达更高、IL-1水平更高且IL-10增加。
表现出促炎反应的不稳定型心绞痛和冠状动脉向外重塑患者经历了复发性冠状动脉事件且总斑块面积百分比增加。相比之下，抗炎反应患者的预后更好。这种反应可能继发于低密度脂蛋白。
