Department of Cardiology, The Second Affiliated Hospital, Nan Tong University, Nantong, Jiangsu 226601, China.
Chin Med J (Engl). 2010 Nov;123(21):3123-6.
Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was to compare concentrations of soluble forms of adhesion molecules in patients with different clinical presentations of coronary artery disease (CAD).
One hundred and twenty-eight patients with CAD were divided into three groups; the first group was acute myocardial infarction group (AMI group, n = 45), the second group was unstable angina pectoris group (UAP group, n = 48), the third group was stable angina pectoris group (SAP group, n = 35). We compared them with patients with normal coronary arteries (control group, n = 31). The serum levels of vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin and P-selectin were measured in all subjects.
The serum level of VCAM-1 in the AMI group was significantly higher than in the UAP, SAP and control groups (P < 0.01). The level in the UAP group was significantly higher than the SAP group and control group (P < 0.01) and the level in the SAP group was significantly higher than in the control group (P < 0.01). The serum ICAM-1 level was significantly elevated in the AMI, UAP and SAP groups as compared to the control group (P < 0.01). The levels of serum E-selectin and P-selectin in the AMI and UAP groups were significantly higher than in the SAP and control groups (P < 0.01).
Increased levels of VCAM-1 and ICAM-1, E-selectin and P-selectin, as markers of inflammation, showed the importance of inflammatory processes in the development of atherosclerosis and clinical expression of CAD. Soluble ICAM-1, VCAM-1, E-selectin and P-selectin concentrations are useful indicators of the presence of atherosclerosis and the severity of CAD clinical presentation.
黏附分子在冠状动脉粥样硬化的发生和发展中起重要作用。本研究旨在比较不同临床表现的冠心病患者可溶性黏附分子的浓度。
128 例冠心病患者分为三组；第一组为急性心肌梗死组（AMI 组，n=45），第二组为不稳定型心绞痛组（UAP 组，n=48），第三组为稳定型心绞痛组（SAP 组，n=35）。我们将其与正常冠状动脉患者（对照组，n=31）进行比较。所有患者均检测血管细胞黏附分子（VCAM-1）、细胞间黏附分子-1（ICAM-1）、E-选择素和 P-选择素的血清水平。
AMI 组血清 VCAM-1 水平明显高于 UAP、SAP 和对照组（P＜0.01）。UAP 组水平明显高于 SAP 组和对照组（P＜0.01），SAP 组水平明显高于对照组（P＜0.01）。与对照组相比，AMI、UAP 和 SAP 组血清 ICAM-1 水平明显升高（P＜0.01）。AMI 和 UAP 组血清 E-选择素和 P-选择素水平明显高于 SAP 组和对照组（P＜0.01）。
炎症标志物 VCAM-1 和 ICAM-1、E-选择素和 P-选择素水平升高，表明炎症过程在动脉粥样硬化的发生和冠心病的临床表现中具有重要作用。可溶性 ICAM-1、VCAM-1、E-选择素和 P-选择素浓度是动脉粥样硬化存在和冠心病临床表现严重程度的有用指标。
