Matsumoto N, Yoshimoto K, Okagawa K, Kosaka M, Saito S
First Dept. of Internal Medicine, School of Medicine, University of Tokushima.
Gan To Kagaku Ryoho. 1989 Jun;16(6):2297-300.
A 58-year-old man with Hodgkin's disease exhibited erythrodermia due to allergic reaction to vincristine sulfate (VCR) and vindesine sulfate (VDS). However, chemotherapy could be continued by changing VCR and VDS to etoposide without allergic symptom. Clinical observation strongly suggested that erythrodermia was due to the use of vinca alkaloids in this patient. Hematological and neurological side effects have been well known for VDS and VCR, but erythrodermia has not yet been reported as being caused by these agents. It is often difficult to differentiate drugs as a cause of an allergic reaction when several drugs are used together. Therefore, it is important to collect all the cases showing the effects of drugs.
一名58岁的霍奇金病患者因对硫酸长春新碱（VCR）和硫酸长春地辛（VDS）过敏反应而出现红皮病。然而，通过将VCR和VDS换为依托泊苷，化疗得以继续且未出现过敏症状。临床观察强烈提示该患者的红皮病是由于使用长春花生物碱所致。VDS和VCR的血液学和神经学副作用已为人熟知，但红皮病尚未见报道由这些药物引起。当同时使用几种药物时，往往难以区分药物作为过敏反应的原因。因此，收集所有显示药物作用的病例很重要。
