术前淡漠帕金森病的丘脑底核刺激相关因素：一项 PET 研究。
Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.
机构信息
From the Academic Department of Psychiatry (G.H.R., C.L., T.D., B.M., D.D.), Guillaume Régnier Hospital, Rennes; Nuclear Medicine Unit (F.L.J.), Oncology Department, Eugène Marquis Center, Rennes; Movement Disorders Unit, Neurology Department (S.D., J.-F.H., M.V.), Academic Department of Psychiatry (D.T.), and Neurophysiology Unit, Neurology Department (P.S.), Rennes University Hospital, France; and Neuroscience of Emotion and Affective Dynamics Laboratory (J.P.), Swiss Center for Affective Sciences, Geneva, Switzerland.
出版信息
Neurology. 2014 Oct 28;83(18):1620-6. doi: 10.1212/WNL.0000000000000941. Epub 2014 Sep 24.
OBJECTIVE
The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease.
METHODS
To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions.
RESULTS
Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS.
CONCLUSIONS
Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
目的
目前的文献对于术前社会人口学和临床因素存在不一致的结果，并且没有关于与苍白术后苍白相关的术前大脑代谢模式的信息苍白在帕金森病的丘脑底核深部脑刺激 (STN-DBS) 之后。
方法
为了解决这个问题，我们着手确定与苍白苍白相关的术前代谢模式和社会人口学及临床因素苍白苍白术后苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白苍白，
Zotero 插件