Department of Physiotherapy, Sakakibara Heart Institute, Tokyo, Japan.
Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Cardiorenal Med. 2014 Aug;4(2):73-81. doi: 10.1159/000362252. Epub 2014 Apr 17.
The aim of this study was to confirm the effects of chronic kidney disease (CKD) and anemia on physical function and to clarify whether the interaction between CKD and anemia has an additive effect.
Eligible subjects were chronic heart failure (HF) patients who were discharged between March 2007 and August 2009. A total of 102 chronic HF patients (33% females; mean age: 68 ± 14 years) were enrolled in the present study. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m(2), and anemia was defined as a hemoglobin level of <12 g/dl in males and of <11 g/dl in females. The Short Physical Performance Battery (SPPB) was used to assess physical function.
The adjusted mean SPPB score was lower in patients with both CKD and anemia than in those with neither of the diseases or with either disease alone (p < 0.05).
This study found that CKD and anemia are independently associated with reduced physical function.
本研究旨在确认慢性肾脏病（CKD）和贫血对身体功能的影响，并阐明 CKD 和贫血之间的相互作用是否具有累加效应。
符合条件的受试者为 2007 年 3 月至 2009 年 8 月出院的慢性心力衰竭（HF）患者。本研究共纳入 102 例慢性 HF 患者（33%为女性；平均年龄：68 ± 14 岁）。CKD 的定义为估计肾小球滤过率<60ml/min/1.73m²，贫血的定义为男性血红蛋白水平<12g/dl，女性血红蛋白水平<11g/dl。采用简短体能状况量表（SPPB）评估身体功能。
同时患有 CKD 和贫血的患者的调整后 SPPB 评分低于既无这两种疾病也无任何一种疾病的患者（p<0.05）。
本研究发现 CKD 和贫血均与身体功能下降独立相关。
