雄性幼鼠的胆碱能成熟与SCH 23390诱导的僵住症

Cholinergic maturation and SCH 23390-induced catalepsy in the male rat pup.

作者信息

Fitzgerald L W, Hannigan J H

机构信息

Department of Psychology, State University of New York, Albany 12222.

出版信息

Brain Res Dev Brain Res. 1989 May 1;47(1):147-50. doi: 10.1016/0165-3806(89)90118-1.

DOI:10.1016/0165-3806(89)90118-1

PMID:2525433

Abstract

The cataleptogenic effects of the selective dopamine D1 receptor antagonist, SCH 23390, increased between 13 and 17 days of age in male pups. Seventeen- and 21-day-old pups showed equivalent catalepsy. Scopolamine blocked SCH 23390-induced catalepsy in 21-day-old pups but had little effect in 13-day-old pups. The development and cholinergic sensitivity of SCH 23390-induced catalepsy are similar to those seen after D2 or mixed D1/D2 receptor blockade. Cholinergic maturation appears to be an important component in the development of adult-like catalepsy, and the nature of a D1-acetylcholine interaction mediating catalepsy remains to be determined.

摘要

选择性多巴胺D1受体拮抗剂SCH 23390的致僵效应在雄性幼崽13至17日龄期间增强。17日龄和21日龄的幼崽表现出同等程度的僵住症。东莨菪碱可阻断21日龄幼崽中由SCH 23390诱导的僵住症，但对13日龄幼崽几乎没有影响。SCH 23390诱导的僵住症的发展及胆碱能敏感性与D2受体阻断或D1/D2受体混合阻断后所见相似。胆碱能成熟似乎是类似成年僵住症发展过程中的一个重要组成部分，介导僵住症的D1 - 乙酰胆碱相互作用的本质仍有待确定。