Lagerburg Vera, Bakkers Mayienne, Bouwhuis Anne, Hoeijmakers Janneke G J, Smit Arjen M, Van Den Berg Sofia J M, Hordijk-De Boer Ineke, Brouwer-Van Der Lee Mardien D G, Kranendonk Douwe, Reulen Jos P H, Faber Catharina G, Merkies Ingemar S J
Department of Clinical Physics, Catharina Hospital, Eindhoven, The Netherlands.
Muscle Nerve. 2015 May;51(5):743-9. doi: 10.1002/mus.24465. Epub 2015 Mar 31.
Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients.
Standardized CHEPs were administered at the wrist and ankle. The N2 and P2 latencies and N2 -P2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n = 97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n = 42). CHEP reproducibility and interobserver values were also investigated.
CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients.
In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN.
接触热诱发电位（CHEP）可能是小纤维神经病变（SFN）的一种客观、非侵入性诊断工具。本研究确定了CHEP的正常值，并探讨了其在SFN患者中的适用性。
在手腕和脚踝处进行标准化的CHEP检测。通过脑电图记录N2和P2潜伏期以及N2 - P2峰峰值幅度。我们研究了按年龄和性别分层的健康受试者（n = 97）以及表皮内神经纤维密度异常的SFN患者（n = 42）。还研究了CHEP的可重复性和观察者间的值。
确定了CHEP的正常值。随着年龄增长，潜伏期每厘米身高增加9 - 16%。女性的振幅高于男性，且随年龄增长而降低（17 - 71%）。重测可重复性和观察者间的值分别>0.61和>0.96。73.8%的患者CHEP异常。
在本研究中，我们确定了CHEP在SFN中的正常值、可靠性和临床适用性。
