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双侧乳内动脉对短期和长期预后的影响:根据当前建议进行倾向评分匹配。

The influence of bilateral internal mammary arteries on short- and long-term outcomes: a propensity score matching in accordance with current recommendations.

作者信息

Benedetto Umberto, Amrani Mohamed, Gaer Jullien, Bahrami Toufan, de Robertis Fabio, Simon André R, Raja Shahzad G

机构信息

Department of Cardiac Surgery, Harefield Hospital, London, United Kingdom.

Department of Cardiac Surgery, Harefield Hospital, London, United Kingdom.

出版信息

J Thorac Cardiovasc Surg. 2014 Dec;148(6):2699-705. doi: 10.1016/j.jtcvs.2014.08.021. Epub 2014 Aug 14.

Abstract

OBJECTIVES

We undertook a single-center, 12 years outcomes analysis of the influence of bilateral internal mammary arteries (BIMA) over single internal mammary artery (SIMA) on short-term outcomes and long-term outcomes by means of propensity score matching technique in accordance to current recommendations.

METHODS

A propensity score was generated for each patient from a multivariable logistic regression model based on 20 pretreatment covariates. The study population consisted of 4195 patients undergoing coronary artery bypass graft procedure using SIMA (n = 3445; 78.3%) or BIMA (n = 750; 21.7%). A total of 750 matching sets were derived.

RESULTS

The BIMA group was associated with an increased rate of superficial sternal wound infection (5.6% vs 1.7%; P = .0001) but the incidence of deep sternal wound infection was comparable between the 2 groups, at 2.1% and 1.5% in BIMA and SIMA groups, respectively (P = .43). With regard to other postoperative complications the 2 groups were comparable. Operative mortality rate did not significantly differ between the 2 groups, at 0.7% and 1.2% in the BIMA and SIMA groups, respectively (P = .28). After a mean follow-up time of 4.8 ± 3.2 years, BIMA use was associated with a significantly lower risk for late mortality (hazard ratio, 0.61; 95% confidence interval 0.38-0.97; P = .03) and need for repeat revascularization (hazard ratio, 0.75; 95% confidence interval, 0.53-0.96; P = .03).

CONCLUSIONS

When compared with SIMA grafting, BIMA use did not increase operative morbidity and mortality and was associated with a better long-term survival.

摘要

目的

我们采用倾向评分匹配技术,根据当前建议,对单中心12年的结果进行分析,以探讨双侧乳内动脉(BIMA)与单支乳内动脉(SIMA)相比对短期和长期结果的影响。

方法

基于20个术前协变量,通过多变量逻辑回归模型为每位患者生成倾向评分。研究人群包括4195例行冠状动脉旁路移植术的患者,其中使用SIMA的患者有3445例(78.3%),使用BIMA的患者有750例(21.7%)。共得到750对匹配组。

结果

BIMA组的胸骨浅表伤口感染率较高(5.6%对1.7%;P = 0.0001),但两组的胸骨深部伤口感染发生率相当,BIMA组和SIMA组分别为2.1%和1.5%(P = 0.43)。在其他术后并发症方面,两组相当。两组的手术死亡率无显著差异,BIMA组和SIMA组分别为0.7%和1.2%(P = 0.28)。平均随访4.8±3.2年后,使用BIMA与较低的晚期死亡风险(风险比,0.61;95%置信区间0.38 - 0.97;P = 0.03)和再次血运重建需求(风险比,0.75;95%置信区间,0.53 - 0.96;P = 0.03)相关。

结论

与SIMA移植相比,使用BIMA不会增加手术发病率和死亡率,且与更好的长期生存率相关。

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