Falah Nadia, Haas David M
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN.
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN.
Semin Perinatol. 2014 Dec;38(8):528-33. doi: 10.1053/j.semperi.2014.08.018. Epub 2014 Sep 23.
Landmark early work has led to the nearly universal use of antenatal corticosteroids to accelerate fetal lung maturity with pregnancies complicated by impending preterm birth. Antenatal corticosteroids clearly reduce respiratory morbidity, death, and other adverse neonatal outcomes. Limited pregnant human pharmacokinetic data and some animal data give clinicians some information as to the behavior of the drug in the body. However, there is controversy about the type, amount, and frequency of steroid to use for this therapy. This review article summarizes the history, clinical use, and pharmacology of antenatal steroids. In addition, the review highlights some potential mediators of steroid response and current research strategies aimed at possible optimization of this therapy.
具有里程碑意义的早期研究成果使得产前使用糖皮质激素以加速胎儿肺成熟在即将早产的妊娠中几乎得到普遍应用。产前糖皮质激素明显降低了呼吸系统发病率、死亡率及其他不良新生儿结局。有限的孕妇人体药代动力学数据以及一些动物数据为临床医生提供了有关该药物在体内行为的一些信息。然而，对于用于该治疗的类固醇的类型、剂量和频率存在争议。这篇综述文章总结了产前类固醇的历史、临床应用和药理学。此外，该综述强调了类固醇反应的一些潜在介质以及旨在可能优化该治疗的当前研究策略。
