Cheung Anson, Stub Dion, Moss Robert, Boone Robert H, Leipsic Jonathon, Verheye Stefan, Banai Shmuel, Webb John
The Centre for Heart Valve Innovation, St Paul's Hospital, Vancouver, Canada.
EuroIntervention. 2014 Sep;10 Suppl U:U115-9. doi: 10.4244/EIJV10SUA17.
Mitral valve surgery is the gold standard therapy for severe mitral regurgitation, but can be associated with significant morbidity and mortality. Percutaneous mitral leaflet repair has recently been established as a viable alternative to surgery, but many patients are ineligible and repair may not be optimal. Transcatheter mitral valve implantation may be an alternate therapeutic option, particularly for high-risk patients. We outline the initial preclinical and first-in-human experience with the Tiara transapical mitral valve implantation system, highlighting the ease of implantation, proven feasibility and excellent haemodynamic performance.
二尖瓣手术是重度二尖瓣反流的金标准治疗方法，但可能伴有显著的发病率和死亡率。经皮二尖瓣瓣叶修复术最近已成为一种可行的手术替代方案，但许多患者不符合条件，且修复可能并非最佳选择。经导管二尖瓣植入术可能是一种替代治疗选择，尤其是对于高危患者。我们概述了Tiara经心尖二尖瓣植入系统的初步临床前和首例人体经验，突出了植入的简便性、已证实的可行性和出色的血流动力学性能。
