通过 RAFT 聚合对静电纺丝醋酸纤维素纳米纤维进行表面改性以吸附 DNA。
Surface modification of electrospun cellulose acetate nanofibers via RAFT polymerization for DNA adsorption.
机构信息
UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey; Department of Chemistry, Faculty of Arts and Sciences, Amasya University, 05100 Amasya, Turkey.
UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey; Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey.
出版信息
Carbohydr Polym. 2014 Nov 26;113:200-7. doi: 10.1016/j.carbpol.2014.06.086. Epub 2014 Jul 11.
We report on a facile and robust method by which surface of electrospun cellulose acetate (CA) nanofibers can be chemically modified with cationic polymer brushes for DNA adsorption. The surface of CA nanofibers was functionalized by growing poly[(ar-vinylbenzyl)trimethylammonium chloride)] [poly(VBTAC)] brushes through a multi-step chemical sequence that ensures retention of mechanically robust nanofibers. Initially, the surface of the CA nanofibers was modified with RAFT chain transfer agent. Poly(VBTAC) brushes were then prepared via RAFT-mediated polymerization from the nanofiber surface. DNA adsorption capacity of CA nanofibrous web surface functionalized with cationic poly(VBTAC) brushes was demonstrated. The reusability of these webs was investigated by measuring the adsorption capacity for target DNA in a cyclic manner. In brief, CA nanofibers surface-modified with cationic polymer brushes can be suitable as membrane materials for filtration, purification, and/or separation processes for DNA.
我们报告了一种简便而稳健的方法，可通过将阳离子聚合物刷化学修饰电纺醋酸纤维素（CA）纳米纤维的表面，用于 DNA 吸附。通过多步化学序列，使 CA 纳米纤维的表面功能化，从而确保保持机械坚固的纳米纤维。首先，通过 RAFT 链转移剂对 CA 纳米纤维的表面进行改性。然后通过从纳米纤维表面进行 RAFT 介导的聚合来制备聚[（芳基乙烯基苄基）三甲基氯化铵] [聚（VBTAC）]刷。证明了用阳离子聚（VBTAC）刷功能化的 CA 纳米纤维网表面的 DNA 吸附能力。通过以循环方式测量目标 DNA 的吸附能力来研究这些网的可重复使用性。简而言之，用阳离子聚合物刷表面修饰的 CA 纳米纤维可用作用于过滤，纯化和/或分离 DNA 的膜材料。
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