Overweg-van Kints J, Blackburn C L, Groen H D, Stricker B H
Ned Tijdschr Geneeskd. 1989 May 13;133(19):988-91.
Four patients developed apnoea after epidural administration of 50 micrograms of sufentanil. In three of these patients apnoea occurred within two minutes after administration. In all cases catheter position was verified to be in the epidural space. It is possible that accumulation plays a causative role in some of those cases in which the drug is given on demand. Because sufentanil-induced apnoea may occur fast and unexpected it is advised that patients should be kept under close supervision for at least two hours following administration.
4例患者在硬膜外给予50微克舒芬太尼后出现呼吸暂停。其中3例患者在给药后两分钟内发生呼吸暂停。所有病例均证实导管位置在硬膜外腔。在按需给药的某些病例中，蓄积可能起了致病作用。由于舒芬太尼引起的呼吸暂停可能迅速且出乎意料地发生，建议给药后至少两小时对患者进行密切监测。
