la Fleur Susanne E, Serlie Mireille J
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreeg 9, F2-154, 1105 AZ Amsterdam, The Netherlands.
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreeg 9, F2-154, 1105 AZ Amsterdam, The Netherlands.
Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):649-59. doi: 10.1016/j.beem.2014.06.001. Epub 2014 Jun 20.
Aberrant feeding behavior can lead to obesity and obesity-related medical consequences, such as insulin resistance and diabetes. Although alterations in glucose metabolism (i.e. insulin resistance), in the presence of excessive fat tissue are often explained by the consequences of dysfunctional adipose tissue, evidence is emerging that also altered brain functions might be an important determinant of insulin resistance. In this review, we provide an overview of how feeding behavior and obesity interact with brain circuitry and how these interactions affect glucose metabolism. Because brain circuitries involved in food intake have been shown to partly control glucose metabolism as well, targeting these circuitries in obese subjects might not only affect food intake and body weight but also glucose metabolism.
异常的进食行为会导致肥胖以及与肥胖相关的医学后果，如胰岛素抵抗和糖尿病。尽管在脂肪组织过多的情况下，葡萄糖代谢的改变（即胰岛素抵抗）通常被解释为脂肪组织功能失调的后果，但越来越多的证据表明，大脑功能的改变也可能是胰岛素抵抗的一个重要决定因素。在这篇综述中，我们概述了进食行为和肥胖如何与大脑回路相互作用，以及这些相互作用如何影响葡萄糖代谢。由于参与食物摄入的大脑回路也已被证明部分控制着葡萄糖代谢，因此针对肥胖受试者的这些回路进行干预，可能不仅会影响食物摄入和体重，还会影响葡萄糖代谢。
