Stalnaker M, Esquivel P
Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.
Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.
J Pediatr Adolesc Gynecol. 2015 Feb;28(1):e9-e12. doi: 10.1016/j.jpag.2014.03.007. Epub 2014 Mar 27.
Factor V deficiency is a rare coagulation disorder. Excessive uterine bleeding is common in affected women. We describe a case of 2 siblings with Factor V deficiency and menorrhagia who achieved control of bleeding with differing treatments.
Patient 1 is a 16-year-old female with Factor V deficiency and menorrhagia which was previously controlled with oral contraceptives (OC). She developed heavy bleeding treated with fresh frozen plasma, anti-inhibitor coagulant complex (AICC), and OC taper. A levonorgestrel IUD was placed with good control of her menorrhagia. Patient 2 is the 12-year-old sister of Patient 1. She was treated with AICC, aminocaproic acid, and her menorrhagia was ultimately controlled with continuous OCs.
Factor V deficiency is a rare cause of menorrhagia. Various treatment modalities are available. In these adolescent sisters desiring future fertility, menorrhagia was managed with OCs and an IUD.
