Lordkipanidze E F, Aladashvili L T, Kakauridze M V
Ortop Travmatol Protez. 1989 Apr(4):11-4.
The aim of this paper was to determine the mechanisms of development or manifestations of the congenital dislocation of the hip by the method of multivariate analysis. The source of information were the family data about 300 children with congenital dislocation of the hip aged from 3 months to 15 years who had not been specially selected from those treated at the Centre and 300 children of the same age from unselected population. All the examinees were Georgians by nationality. Clinical methods of examination were employed. The results of the cluster analysis showed that the system of prognostic signs of the congenital dislocation of the hip consisted of 13 clusters in the experimental group (4 independent and 9 correlated) and of 13 clusters in the control group (5 independent and 8 correlated). The signs under investigation comprised the following groups of probable factors of the congenital dislocation of the hip: social-biological, geographical, obstetrical-gynecological, risk factors during the pregnancy, risk factors during the child birth on the mother's part, risk factors on the child's part, perinatal factors, postnatal factors, abnormalities of the child and its relatives. The obtained system of prognosis is well agreed with the biological mechanisms of the congenital dislocation of the hip. These data may be used for making perinatal and preclinical diagnosis, for raising the efficiency of medicogenetic consultations and for the initial orthopaedic prevention of the disease.
本文旨在通过多变量分析方法确定先天性髋关节脱位的发展机制或表现形式。信息来源是关于300名年龄在3个月至15岁之间的先天性髋关节脱位儿童的家庭数据，这些儿童并非从该中心接受治疗的患儿中特意挑选出来的，以及300名来自未经过挑选人群的同年龄段儿童。所有受检者均为格鲁吉亚国籍。采用了临床检查方法。聚类分析结果表明，先天性髋关节脱位的预后体征系统在实验组由13个聚类组成（4个独立聚类和9个相关聚类），在对照组由13个聚类组成（5个独立聚类和8个相关聚类）。所研究的体征包括以下几组先天性髋关节脱位的可能因素：社会生物学因素、地理因素、妇产科因素、孕期危险因素、母亲分娩时的危险因素、患儿自身的危险因素、围产期因素、产后因素、患儿及其亲属的异常情况。所获得的预后系统与先天性髋关节脱位的生物学机制高度吻合。这些数据可用于进行围产期和临床前诊断，提高药物遗传学咨询的效率以及对该疾病进行初步的骨科预防。
