de Cornelissen F, Bermudes H, Saint-Loubert M, Marty L, Emond C, Fontanier P
Service de Néphrologie-Hémodialyse, Centre hospitalier, Carcassonne.
Presse Med. 1989 Jun 24;18(25):1243-4.
The possibility of obtaining a rapid fall of kalaemia in patients with renal failure under haemodialysis by injecting salbutamol intravenously in doses of 0.5 mg over 15 minutes was tested in 11 subjects. Kalaemia fell by 1.08 +/- 0.30 mmol in 30 minutes, 75 per cent of the effect being obtained at the end of the infusion. Malaise with tachycardia was frequent but always transient. Thus, a rapid infusion of salbutamol seems to be well tolerated and effective against hyperkalaemia, provided two contra-indications are observed: coronary disease and treatment with beta-blockers.
对11名受试者进行了测试，以检验在15分钟内静脉注射0.5毫克沙丁胺醇是否有可能使接受血液透析的肾衰竭患者的血钾迅速下降。血钾在30分钟内下降了1.08±0.30毫摩尔，75%的效果在输注结束时获得。伴有心动过速的不适很常见，但总是短暂的。因此，快速输注沙丁胺醇似乎耐受性良好且对高钾血症有效，前提是注意两个禁忌证：冠状动脉疾病和β受体阻滞剂治疗。
