Lemeshko V V, Malanda P
Ukr Biokhim Zh (1978). 1989 Jan-Feb;61(1):64-71.
It is established that at the early stage of total heart ischemia in rats (5-10 min) the oligomycin-sensitive ATPase activity of mitochondria measured in heart homogenates in the medium and containing no Mg2+ decreases considerably, whereas the activity of respiratory chain, the value of respiratory control and Mg2+-ATPase activity are practically unchanged. The hypothetic trigger mechanism is suggested for Mg2+ ejection from mitochondria under conditions of respiration cessation. It is supposed to be a defence reaction of cells aimed to prevent ATP hydrolysis by mitochondria under ischemia.
已经确定，在大鼠全心缺血的早期阶段（5 - 10分钟），在不含Mg2 +的培养基中测定的心脏匀浆中线粒体的寡霉素敏感ATP酶活性显著降低，而呼吸链活性、呼吸控制值和Mg2 + -ATP酶活性实际上没有变化。提出了在呼吸停止条件下线粒体中Mg2 +排出的假设触发机制。推测这是细胞的一种防御反应，旨在防止缺血状态下线粒体对ATP的水解。
