Celik Tamer, Celik Umit, Donmezer Cigdem, Komur Mustafa, Tolunay Orkun, Demirtürk Pelin
Pediatric Neurology, Adana Numune Research and Training Hospital, Adana, Turkey.
Pediatrics, Adana Numune Research and Training Hospital, Adana, Turkey.
Case Rep Pediatr. 2014;2014:831398. doi: 10.1155/2014/831398. Epub 2014 Sep 1.
Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in literature. They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier's disease and epilepsy. We also revised current English literature on this topic.
毛囊角化病是一种皮肤疾病，其特征为在脂溢性区域出现多发性角化过度或结痂丘疹，并伴有组织学上的棘层松解和角化不良。它由单个基因突变引起，该基因是ATP2A2，在皮肤和大脑中表达。文献中经常报道毛囊角化病与各种神经和精神疾病同时发生。这些疾病包括情绪障碍、癫痫、脑病和精神分裂症。在本研究中，我们报告了一例同时患有毛囊角化病和癫痫的儿科病例。我们还查阅了关于该主题的当前英文文献。
