Silberberg J S, Rahal D P, Patton D R, Sniderman A D
Division of Cardiology, Royal Victoria Hospital, Montreal, Quebec, Canada.
Am J Cardiol. 1989 Jul 15;64(3):222-4. doi: 10.1016/0002-9149(89)90462-1.
Left ventricular (LV) hypertrophy is common in end-stage renal disease, yet the factors associated with its development are poorly understood. LV mass index was determined by echocardiography in 78 patients who had been treated by dialysis for at least 3 months. A significant relation was evident between anemia and LV hypertrophy. The mean LV mass index was 158 +/- 6 g/m2 (mean +/- standard error) in patients in the lowest quartile of serum hemoglobin and 140 +/- 10, 132 +/- 7 and 120 +/- 8 g/m2 in the second, third and uppermost quartiles, respectively (p = 0.005). This relation persisted after adjusting for systolic blood pressure, treatment mode and suspected coronary artery disease. Forty-eight patients had paired studies. In these, LV mass index increased as hemoglobin decreased (coefficient = -0.81 g/m2/g/liter, p less than 0.025). These data indicate that anemia contributes to the development of LV hypertrophy in patients with end-stage renal disease.
左心室肥厚在终末期肾病中很常见，但与其发生相关的因素却知之甚少。通过超声心动图测定了78例接受透析治疗至少3个月患者的左心室质量指数。贫血与左心室肥厚之间存在显著关联。血清血红蛋白处于最低四分位数的患者，平均左心室质量指数为158±6 g/m²（平均值±标准误），而在第二、第三和最高四分位数的患者中，该指数分别为140±10、132±7和120±8 g/m²（p = 0.005）。在对收缩压、治疗方式和疑似冠状动脉疾病进行校正后，这种关联依然存在。48例患者进行了配对研究。在这些研究中，随着血红蛋白水平下降，左心室质量指数升高（系数=-0.81 g/m²/g/升，p<0.025）。这些数据表明，贫血促使终末期肾病患者发生左心室肥厚。
