Ryzhakov Grigory, Eames Hayley L, Udalova Irina A
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford , Oxford, United Kingdom .
J Interferon Cytokine Res. 2015 Feb;35(2):71-8. doi: 10.1089/jir.2014.0023. Epub 2014 Sep 26.
Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. Upon induction of immune signaling pathways, IRF5 undergoes post-translational modifications such as phosphorylation and ubiqutination, which are believed to trigger IRF5 nuclear translocation from the cytosol, followed by recruitment to promoters where transcription of its gene targets is initiated. In this review, we systematically analyze the data published in the last decade on IRF5 activation, including the role of post-translational modifications and the proposed enzymes targeting IRF5 in this process. We discuss suggested models of IRF5 activation in connection to pathway-specific functions of IRF5.
干扰素调节因子5（IRF5）是众多免疫和稳态过程中的关键转录因子，这些过程包括宿主对病原体的防御、肿瘤发生和自身免疫。在免疫信号通路被诱导时，IRF5会经历翻译后修饰，如磷酸化和泛素化，据信这些修饰会触发IRF5从细胞质向细胞核的转运，随后被招募到启动子区域，在那里启动其基因靶标的转录。在这篇综述中，我们系统地分析了过去十年中发表的关于IRF5激活的数据，包括翻译后修饰的作用以及在此过程中靶向IRF5的假定酶。我们结合IRF5的特定通路功能，讨论了IRF5激活的建议模型。
