Valdespino-Gómez Víctor Manuel, Valdespino-Castillo Patricia Margarita, Valdespino-Castillo Víctor Edmundo
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana, Unidad Xochimilco, México DF, Mexico.
Instituto de Ecología, Universidad Nacional Autónoma de México, México DF, Mexico.
Cir Cir. 2014 Sep-Oct;82(5):578-89.
Regenerative medicine is a medical multidisciplinary area with the aim of morphologic and functional restoration of tissues or organs in order to re-establish normal function. The main bases of regenerative medicine are the use of autologous stem or progenitor cells and the ex vivo construction of physical-mechanical tissue structuring organization, which with stem cells may form bioartificial organs. Another eventual strategy is in vivo stem or progenitor cell stimulation for proliferation. Tissue engineering entirely combines the use of cells, biochemical and physicochemical factors, nanomaterials and bioengineering methods to improve or replace biological functions of tissues and organs. The progressive understanding of the proliferation and differentiation of the process of stem cells and their in vitro manipulation has been the launching platform for the field of regenerative medicine. In this review we describe the main strategies used for regenerative medicine in tissue regeneration along with the main obtained clinicalsurgical benefits.
再生医学是一个医学多学科领域，其目的是使组织或器官在形态和功能上得到恢复，从而重建正常功能。再生医学的主要基础是使用自体干细胞或祖细胞，以及在体外构建物理机械组织结构，该结构与干细胞一起可形成生物人工器官。另一种可能的策略是在体内刺激干细胞或祖细胞增殖。组织工程完全结合了细胞、生化和物理化学因素、纳米材料以及生物工程方法的使用，以改善或替代组织和器官的生物学功能。对干细胞增殖和分化过程及其体外操作的逐步了解一直是再生医学领域的启动平台。在这篇综述中，我们描述了在组织再生中用于再生医学的主要策略以及主要获得的临床手术益处。
