9-脱氧类似物（-）-千里光酮的合成与评价，一种 HRV3C 蛋白酶抑制剂。
Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease.
机构信息
School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland 1142, New Zealand; School of Biological Sciences, The University of Auckland, 3A Symonds St., Auckland 1010, New Zealand.
School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland 1142, New Zealand.
出版信息
Eur J Med Chem. 2014 Nov 24;87:220-7. doi: 10.1016/j.ejmech.2014.09.063. Epub 2014 Sep 22.
PMID:25259514
Abstract
9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme.
摘要
HRV 3C 蛋白酶抑制剂 (-)-thysanone 的 9-脱氧类似物比天然产物显示出更好的抑制特性，这表明 C9-OH 阻碍了与酶的结合。
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