Ferrario Marina, Secomandi Rita, Cappato Matteo, Galbignani Ester, Frigerio Luigi, Arnoldi Mariangela, Fusi Francesco M
Reproductive Medicine Unit, Ospedale Papa Giovanni XXIII , Bergamo , Italy and.
Gynecol Endocrinol. 2015 Feb;31(2):125-30. doi: 10.3109/09513590.2014.964639. Epub 2014 Sep 26.
The aim of this retrospective analysis was to evaluate the association between serum levels of various hormones and in vitro fertilization (IVF) parameters in poor responder patients. Serum levels of anti-Müllerian hormone (AMH), dehydroepiandrosterone sulfate (DHEAS), androstenedione and testosterone were measured before the start of IVF treatment cycle. We found that serum AMH and DHEAS levels were positively correlated with the number of mature oocytes, fertilized oocytes and developed embryos, both in pregnant and in non-pregnant patients. In contrast, we found a positive correlation between serum androstenedione levels and IVF parameters in pregnant, but not in non-pregnant patients. In this latter group, androstenedione levels were positively associated with the number of mature oocytes and were negatively correlated with the number of fertilized oocytes. No correlation was observed with developed embryos. Finally, we reported a negative correlation between serum levels of testosterone and IVF parameters in pregnant women whereas no correlation was observed in non-pregnant patients. Our results suggest that serum AMH and DHEAS could be predictive for oocyte retrieval and embryo development. Moreover, the positive correlation between serum androstenedione levels and IVF parameters in pregnant patients, together with the lack of a consistent correlation in non-pregnant women seem to identify androstenedione as a more predictive marker for pregnancy outcome than testosterone. In addition, in our analysis testosterone shows a negative correlation with IVF parameters.
这项回顾性分析的目的是评估反应不良患者血清中各种激素水平与体外受精（IVF）参数之间的关联。在IVF治疗周期开始前，测量血清抗苗勒管激素（AMH）、硫酸脱氢表雄酮（DHEAS）、雄烯二酮和睾酮水平。我们发现，无论是怀孕患者还是未怀孕患者，血清AMH和DHEAS水平与成熟卵母细胞、受精卵母细胞和发育胚胎的数量均呈正相关。相比之下，我们发现怀孕患者血清雄烯二酮水平与IVF参数呈正相关，而未怀孕患者则不然。在后一组中，雄烯二酮水平与成熟卵母细胞数量呈正相关，与受精卵母细胞数量呈负相关。与发育胚胎数量未观察到相关性。最后，我们报告怀孕女性血清睾酮水平与IVF参数呈负相关，而未怀孕患者未观察到相关性。我们的结果表明，血清AMH和DHEAS可预测卵母细胞采集和胚胎发育。此外，怀孕患者血清雄烯二酮水平与IVF参数呈正相关，而未怀孕女性缺乏一致的相关性，这似乎表明雄烯二酮比睾酮更能预测妊娠结局。此外，在我们的分析中，睾酮与IVF参数呈负相关。
