Becherer J D, Alsenz J, Servis C, Myones B L, Lambris J D
Basel Institute for Immunology, Switzerland.
Complement Inflamm. 1989;6(3):142-65. doi: 10.1159/000463091.
The biologic activities mediated by the products of complement activation include cellular, bacterial, and viral lysis, inflammation, phagocytosis, and immunoregulation. These responses are achieved through the interaction of the activated forms of several of the complement proteins with cell membrane proteins. This report reviews aspects of the structure, ligand specificity, and function of the various complement receptors with particular emphasis on those receptors which bind to the activated fragments of C3. In addition, we briefly summarize the surface proteins on foreign particles that bind C3 and their possible role in the pathogenesis of these organisms.
补体激活产物介导的生物学活性包括细胞、细菌和病毒裂解、炎症、吞噬作用和免疫调节。这些反应是通过几种补体蛋白的活化形式与细胞膜蛋白的相互作用来实现的。本报告回顾了各种补体受体的结构、配体特异性和功能等方面，特别强调了那些与C3活化片段结合的受体。此外，我们简要总结了结合C3的外来颗粒表面蛋白及其在这些生物体发病机制中的可能作用。
