Momtaz Yadollah Abolfathi, Ibrahim Rahimah, Hamid Tengku Aizan, Chai Sen Tyng
Institute of Gerontology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Institute of Gerontology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia Department of Human Development and Family Studies, Faculty of Human Ecology, Institute of Gerontology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Am J Alzheimers Dis Other Demen. 2015 Jun;30(4):405-11. doi: 10.1177/1533317514552318. Epub 2014 Sep 26.
Previous studies have shown conflicting results on the association between smoking and cognitive function. This study aims to examine the relationship of smoking with cognitive function.
Data for the study, consisting of 2553 older adults aged 60 years and older, were drawn from a nationwide household survey entitled "Determinants of Wellness among Older Malaysians: A Health Promotion Perspective" conducted in 2010.
Current smokers had lower rates of cognitive impairment compared to never smokers (17.4% vs 25.9%), while cognitive function in former or ex-smokers was almost similar to that of the never smokers. Findings from multiple logistic regression analysis showed that current smokers were 37% less likely to be cognitively impaired, compared to the never smokers (odds ratio [OR] = .63; 95% confidence interval [CI]: .46-.86) while controlling for potential confounders. No difference in cognitive function was observed between former smokers and never smokers (OR = .94; 95% CI: .71-1.25).
Although the findings indicated a negative association between cigarette smoking and cognitive impairment, we are unable to conclude whether this relationship is causal or affected by other unmeasured confounding factors, especially survival bias.
先前的研究在吸烟与认知功能之间的关联上得出了相互矛盾的结果。本研究旨在探讨吸烟与认知功能之间的关系。
该研究的数据来自于2010年进行的一项名为“马来西亚老年人健康的决定因素：健康促进视角”的全国性家庭调查，由2553名60岁及以上的老年人组成。
与从不吸烟者相比，当前吸烟者的认知障碍发生率较低（17.4%对25.9%），而曾经吸烟者或戒烟者的认知功能与从不吸烟者几乎相似。多元逻辑回归分析结果显示，在控制潜在混杂因素的情况下，与从不吸烟者相比，当前吸烟者发生认知障碍的可能性低37%（优势比[OR]=0.63；95%置信区间[CI]：0.46 - 0.86）。曾经吸烟者与从不吸烟者之间未观察到认知功能差异（OR = 0.94；95% CI：0.71 - 1.25）。
尽管研究结果表明吸烟与认知障碍之间存在负相关，但我们无法确定这种关系是否为因果关系，或者是否受到其他未测量的混杂因素影响，尤其是生存偏差。
