Nascimento Camila, Kim Helena Kyunghee, Young L Trevor, Mendonça Karina Martinez, Grinberg Lea Tenenholz, Lafer Beny, Andreazza Ana Cristina
Discipline of Pathophisiology, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 - Cerqueira César, 1° andar, sala 1353, 01246903, São Paulo, SP, Brazil.
J Neural Transm (Vienna). 2015 Jun;122(6):741-6. doi: 10.1007/s00702-014-1318-8. Epub 2014 Sep 27.
The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration.
本研究的目的是阐明谷胱甘肽是否参与锂降低由复合体I抑制所产生的羰基化和硝化作用的能力，这种现象在双相情感障碍（BD）中一直存在。用鱼藤酮（一种复合体I抑制剂）处理神经母细胞瘤细胞。我们的结果表明，谷胱甘肽对于锂改善鱼藤酮诱导的蛋白质羰基化能力至关重要，但对硝化作用并非如此。
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