对法氏囊内 IgG 阳性细胞起源的新认识。

New insight into the origin of IgG-bearing cells in the bursa of Fabricius.

机构信息

Department of Histology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.

出版信息

Int Rev Cell Mol Biol. 2014;312:101-37. doi: 10.1016/B978-0-12-800178-3.00004-X.

Abstract

The bursa of Fabricius is a primary lymphoid organ for B-cell development and gut-associated lymphoid tissue. After hatching, IgG-containing cells with reticular branches are found in the medulla of bursal follicles on frozen sections stained with anti-Cγ antibody, and IgM(+)IgG(+) B cells are detected in single-cell suspension of the bursa. IgG-containing cells in the medulla do not biosynthesize IgG and are composed of aggregated maternal IgG and environmental antigens. Then, those cells in the medulla are acknowledged as follicular dendritic cells retaining immune complexes. Also, it is presumed that IgM(+)IgG(+) B cells are generated by the attachment of immune complexes to IgM(+) bursal B cells because IgM(+)IgG(+) B cells are induced by antigen-dependent attachment of maternal IgG. Therefore, it is reasonable to suppose that immune complexes exert further B-cell differentiation in the medulla.

摘要

法氏囊是 B 细胞发育和肠道相关淋巴组织的主要淋巴器官。孵化后，用抗 Cγ 抗体染色的冷冻切片中可在囊泡滤泡髓质中发现含有网状分支的 IgG 细胞，并且在囊的单细胞悬浮液中可检测到 IgM(+)IgG(+)B 细胞。髓质中的 IgG 细胞不合成 IgG，并且由聚集的母体 IgG 和环境抗原组成。然后，那些髓质中的细胞被认为是保留免疫复合物的滤泡树突状细胞。此外，据推测 IgM(+)IgG(+)B 细胞是通过免疫复合物附着在 IgM(+)囊泡 B 细胞上产生的，因为 IgM(+)IgG(+)B 细胞是由母体 IgG 的抗原依赖性附着诱导的。因此，可以合理地假设免疫复合物在髓质中发挥进一步的 B 细胞分化作用。