对“类风湿关节炎中IV型肽基精氨酸脱亚氨酶（PADI4）单倍型与共同表位相互作用，与抗环瓜氨酸肽抗体或侵蚀性关节状态无关：一项病例对照研究”的回应 - Suppr

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超能文献

Response to 'Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study'.

作者信息

Ikari Katsunori, Yano Koichiro, Yoshida Shinji, Taniguchi Atsuo, Yamanaka Hisashi, Momohara Shigeki

出版信息

Arthritis Res Ther. 2014 Aug 27;16(5):422. doi: 10.1186/s13075-014-0422-3.

DOI:10.1186/s13075-014-0422-3

PMID:25263166

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4145539/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ff/4145539/e87c58f3a86a/13075_2014_422_Fig1_HTML.jpg

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Response to 'Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study'.对“类风湿关节炎中IV型肽基精氨酸脱亚氨酶（PADI4）单倍型与共同表位相互作用，与抗环瓜氨酸肽抗体或侵蚀性关节状态无关：一项病例对照研究”的回应

Arthritis Res Ther. 2014 Aug 27;16(5):422. doi: 10.1186/s13075-014-0422-3.

Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.四型肽基精氨酸脱亚氨酶（PADI4）单倍型与共享表位相互作用，与抗环瓜氨酸肽抗体或类风湿关节炎的侵蚀性关节状态无关：一项病例对照研究。

Arthritis Res Ther. 2010;12(3):R115. doi: 10.1186/ar3051. Epub 2010 Jun 10.

Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis.早期类风湿关节炎中抗环瓜氨酸肽抗体水平与肽基精氨酸脱亚氨酶4（PADI4）单倍型以及极晚期类风湿关节炎中与共享表位等位基因的关联。

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Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies.类风湿性关节炎患者中肽基精氨酸脱亚氨酶瓜氨酸化酶基因功能单倍型的患病率：抗瓜氨酸化肽抗体的存在无影响。

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Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.4型肽基精氨酸脱氨酶基因型和共同表位对类风湿关节炎临床特征及自身抗体谱的影响

Ann Rheum Dis. 2009 Jun;68(6):898-903. doi: 10.1136/ard.2008.091983. Epub 2008 Jul 16.

Polymorphisms and functional haplotype in PADI4: further evidence for contribution on rheumatoid arthritis susceptibility and anti-cyclic citrullinated peptide antibodies in a western Mexican population.肽基精氨酸脱亚氨酶4（PADI4）的多态性与功能单倍型：墨西哥西部人群中类风湿关节炎易感性及抗环瓜氨酸肽抗体相关性的进一步证据

Immunol Lett. 2015 Feb;163(2):214-20. doi: 10.1016/j.imlet.2014.10.029. Epub 2015 Jan 3.

[Association between the synovial expression of cyclic citrullinated peptide and susceptibility variants of HLA-DRB1 shared epitope alleles and PADI 4 gene single nucleotide polymorphisms in patients with rheumatoid arthritis].[类风湿关节炎患者中环状瓜氨酸化肽的滑膜表达与HLA-DRB1共享表位等位基因的易感性变异及肽基精氨酸脱亚胺酶4基因单核苷酸多态性之间的关联]

Zhonghua Yi Xue Za Zhi. 2012 Jun 19;92(23):1607-11.

Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies.肽基精氨酸脱亚胺酶4（PADI4）的功能单倍型：与类风湿关节炎特异性滑膜细胞内瓜氨酸化蛋白及抗瓜氨酸化蛋白抗体的相关性

Ann Rheum Dis. 2005 Sep;64(9):1316-20. doi: 10.1136/ard.2004.033548. Epub 2005 Mar 10.

A functional haplotype of PADI4 gene in rheumatoid arthritis: positive correlation in a French population.类风湿关节炎中PADI4基因的一个功能性单倍型：在法国人群中的正相关性。

J Rheumatol. 2009 May;36(5):881-6. doi: 10.3899/jrheum.080398. Epub 2009 Mar 30.

Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study.德国类风湿性关节炎患者中肽基精氨酸脱亚氨酶4变异性的详细分析：一项病例对照研究。

Arthritis Res Ther. 2006;8(2):R34. doi: 10.1186/ar1889. Epub 2006 Jan 16.

引用本文的文献

Hypoxia‑induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis.缺氧诱导的自噬被 PADI4 敲低抑制，从而促进类风湿关节炎成纤维样滑膜细胞的凋亡。

Mol Med Rep. 2018 Apr;17(4):5116-5124. doi: 10.3892/mmr.2018.8501. Epub 2018 Jan 26.

本文引用的文献

Genetics of rheumatoid arthritis contributes to biology and drug discovery.类风湿关节炎的遗传学研究有助于生物学和药物发现。

Nature. 2014 Feb 20;506(7488):376-81. doi: 10.1038/nature12873. Epub 2013 Dec 25.

PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study.PADI4 和 HLA-DRB1 是 RA 患者影像学进展的遗传风险因素，与 ACPA 状态无关：IORRA 队列研究结果。

PLoS One. 2013;8(4):e61045. doi: 10.1371/journal.pone.0061045. Epub 2013 Apr 8.

Arthritis Res Ther. 2010;12(3):R115. doi: 10.1186/ar3051. Epub 2010 Jun 10.

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.编码瓜氨酸化酶肽基精氨酸脱亚氨酶4的PADI4功能单倍型与类风湿性关节炎相关。

Nat Genet. 2003 Aug;34(4):395-402. doi: 10.1038/ng1206.

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