Li Gongxin, Wang Luzhao, Liu Peng, Wen Zhibo, Huang Fanheng, Chen Liheng, Zhao Xin, Lin Lin, Zhou Yijun
Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Aug;34(9):1324-8.
To investigate the feasibility of Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography (USPIO-MRA) combined with interleukin-6 (IL-6) and IL-10 detection for detecting atherosclerotic plaques in rabbits.
Twenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10.
The rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups.
USPIO-MRA combined with IL-6 and IL-10 detection is feasible in detecting atherosclerotic plaques in rabbits.
探讨超小型超顺磁性氧化铁增强磁共振血管造影（USPIO-MRA）联合白细胞介素-6（IL-6）及IL-10检测在兔动脉粥样硬化斑块检测中的可行性。
将24只正常雄性兔随机分为3组（每组8只）：A组采用Foley管损伤主动脉内膜并结合高脂饮食诱导动脉粥样硬化；B组单纯给予高脂饮食；C组不做任何干预。12周时，对24只兔均行平扫及USPIO-MRA检查，并与病理检查结果进行比较；从耳静脉采集血样检测血脂及IL-6和IL-10水平。
A组和B组兔的IL-6水平差异有统计学意义（167±21.3比116±14.3 pg/ml，P<0.05），但血脂及IL-10水平相当（P>0.05）。A组与C组、B组与C组之间的IL-6、IL-10、总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL）水平差异有统计学意义（P<0.01），但高密度脂蛋白（HDL）水平差异无统计学意义。连续MRA扫描显示3组之间的信噪比（SNR）差异有统计学意义。
USPIO-MRA联合IL-6及IL-10检测在兔动脉粥样硬化斑块检测中是可行的。
