[不同生化标志物在急性心肌梗死早期诊断中的价值]
[Value of different biochemical markers in early diagnosis of acute myocardial infarction].
作者信息
Wang Yarong, Guo Zhuangbo, Huang Liping
机构信息
Department of Cardiology, Fourth Affiliated Hospital, Medical College of Jinan University, Guangzhou Red-Cross Hospital, Guangzhou 510220, China. E-mail:
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2014 Aug;34(9):1347-50.
OBJECTIVE
To study the value of the biochemical markers heart fatty acid binding protein (H-FABP), creatine kinase isoenzyme-MB (CK-MB), myocardial troponin T (cTnT) in early diagnosis of acute myocardial infarction (AMI).
METHODS
Serum levels of H-FABP, CK-MB, and cTNT were detected in 95 patients with confirmed AMI at different time points following the onset in comparison with the data from 43 patients without AMI. The sensitivity and specificity of H-FABP in different phases following the onset were compared between those of CK-MB and cTnT.
RESULTS
Serum H-FABP activities increased significantly within 3 h after the onset of AMI (P<0.01) and continued to increase at 3-6 h and 6-12 h (P<0.001). Serum level of CK-MB within 6 h and cTnT level within 3 h after AMI onset did not show obvious changes (P<0.05). Both the diagnostic sensitivity and specificity of H-FABP within 3 h and within 3-6 h were higher than those CK-MB and cTnT (P<0.05).
CONCLUSION
H-FABP is superior to CK-MB and cTnT in early diagnosis (within 3 h and 3-6 h following the onset) of AMI.
目的
研究心脏脂肪酸结合蛋白（H-FABP）、肌酸激酶同工酶-MB（CK-MB）、心肌肌钙蛋白T（cTnT）这几种生化标志物在急性心肌梗死（AMI）早期诊断中的价值。
方法
检测95例确诊为AMI的患者发病后不同时间点的血清H-FABP、CK-MB和cTNT水平，并与43例非AMI患者的数据进行比较。比较发病后不同阶段H-FABP与CK-MB、cTnT的敏感性和特异性。
结果
AMI发病后3小时内血清H-FABP活性显著升高（P<0.01），在3-6小时及6-12小时持续升高（P<0.001）。AMI发病后6小时内血清CK-MB水平及3小时内cTnT水平无明显变化（P<0.05）。发病后3小时内及3-6小时内H-FABP的诊断敏感性和特异性均高于CK-MB和cTnT（P<0.05）。
结论
在AMI发病后早期（发病后3小时内及3-6小时内）诊断方面，H-FABP优于CK-MB和cTnT。
Zotero 插件