鞘内注射巴氯芬治疗溺水后脑损伤儿童：病例系列
Intrathecal baclofen therapy in children with acquired brain injuries after drowning: A case series.
作者信息
Walter Matthias, Altermatt Stefan, Furrer Claudia, Meyer-Heim Andreas
机构信息
Neuro-Urology, Spinal Cord Injury Centre & Research, University of Zurich, Balgrist University Hospital , Zurich , Switzerland .
出版信息
Brain Inj. 2015;29(1):98-103. doi: 10.3109/02699052.2014.947630. Epub 2014 Sep 29.
UNLABELLED
Objective: To investigate clinical efficacy as well as the incidence and extent of complications regarding intrathecal baclofen (ITB) therapy in children.
METHODS
This is a retrospective medical chart review of three paediatric patients with acquired brain injuries (ABI) resulting from drowning who underwent ITB pump implantation for treatment of severe spasticity.
RESULTS
Compared to the pre-operative state, ITB therapy reduced spasticity with a corresponding decrease of modified Ashworth scale in upper (3.2 ± 1.4 to 1.3 ± 0.6) and lower extremities (3.5 ± 0.9 to 2.0 ± 1.0). Overall, six complications, five device-related and one accidental, were found in two out of three patients.
CONCLUSION
Intrathecal baclofen is an effective therapy option for paediatric patients with ABI after drowning to significantly reduce spasticity of upper and lower extremities. A word of caution must be addressed to the incidence and extent of complications related to ITB therapy.
未标注
目的：探讨鞘内注射巴氯芬（ITB）治疗儿童的临床疗效以及并发症的发生率和严重程度。
方法
这是一项对三名因溺水导致获得性脑损伤（ABI）的儿科患者进行的回顾性病历审查，这些患者接受了ITB泵植入术以治疗严重痉挛。
结果
与术前状态相比，ITB治疗降低了痉挛程度，上肢改良Ashworth量表评分相应降低（从3.2±1.4降至1.3±0.6），下肢评分也相应降低（从3.5±0.9降至2.0±1.0）。总体而言，三名患者中有两名出现了六种并发症，其中五种与设备相关，一种为意外情况。
结论
鞘内注射巴氯芬是溺水后患有ABI的儿科患者有效降低上下肢痉挛的治疗选择。必须注意与ITB治疗相关的并发症的发生率和严重程度。
Zotero 插件