Cuff C F, Taub D D, Rogers T J
Department of Microbiology and Immunology, Temple University School of Medicine, Philadephia, Pennsylvania 19140.
Cell Immunol. 1989 Aug;122(1):71-82. doi: 10.1016/0008-8749(89)90149-4.
We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with dithiothreitol which exerts immunosuppressive activity. This extract is capable of inducing antigen-nonspecific suppressor cells which inhibit the antibody response of normal cells in coculture. Both primary and secondary antibody responses are suppressed by these cells. Our results also show that the suppressor cell population is a member of the L3T4+ Ly-1+ Lyt-2- T-cell lineage. These results provide evidence that Candida extracts may possess clinically significant immunomodulatory activities.
我们之前已经表明，白色念珠菌的全细胞制剂在体内和体外均能够诱导免疫抑制性B细胞活性。为了鉴定表现出这种免疫调节活性的酵母成分，我们成功地用二硫苏糖醇制备了一种具有免疫抑制活性的可溶性提取物。这种提取物能够诱导抗原非特异性抑制细胞，在共培养中抑制正常细胞的抗体反应。初次和二次抗体反应均被这些细胞抑制。我们的结果还表明，抑制细胞群体是L3T4 + Ly-1 + Lyt-2 - T细胞谱系的成员。这些结果证明白色念珠菌提取物可能具有临床上显著的免疫调节活性。
