Kröger Liisa, Putto-Laurila Anne, Vähäsalo Paula, Malin Merja, Aalto Kristiina
Duodecim. 2014;130(16):1615-21.
Systemic onset juvenile idiopathic arthritis is a rare form of juvenile arthritis in which, contrary to autoimmune diseases in general, no association with a certain tissue type has been detected. Together with this fact, the lack of autoantibodies and the general symptoms belonging to the diagnostic criteria of the illness such as high fever, rather speak for its classification into autoinflammatory diseases. Treatment is usually started with anti-inflammatory drugs, often requiring combination with a systemic glucocorticoid. Recognition of interleukins 1 and 6 as central mediators in the pathogenesis of the disease has brought new possibilities for its treatment.
全身型幼年特发性关节炎是幼年关节炎的一种罕见形式，与一般的自身免疫性疾病不同，尚未检测到它与特定组织类型有关联。鉴于这一事实，缺乏自身抗体以及该疾病诊断标准中的一般症状（如高烧），更表明应将其归类为自身炎症性疾病。治疗通常从使用抗炎药物开始，常常需要联合全身性糖皮质激素。认识到白细胞介素1和6是该疾病发病机制的核心介质为其治疗带来了新的可能性。
