• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.选择性生长激素缺乏和内源性生长激素过多对雄性小鼠肌肉和肝脏中胰岛素介导作用的差异影响。
Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.
2
Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis.生长激素受体 (GHR)-信号对肝糖酵解、从头脂肪生成和胰岛素敏感性的直接和系统作用，与脂肪变性有关。
Metabolism. 2023 Jul;144:155589. doi: 10.1016/j.metabol.2023.155589. Epub 2023 May 13.
3
Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.细胞因子信号转导抑制因子2缺陷诱导的分子和代谢变化与生长激素依赖性效应部分重叠。
Mol Endocrinol. 2005 Mar;19(3):781-93. doi: 10.1210/me.2004-0040. Epub 2004 Nov 24.
4
Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.由于生长激素/胰岛素样生长因子-I（IGF-I）特异性丧失，导致生长激素/IGF-I 通路功能丧失，从而改变葡萄糖稳态和胰岛素敏感性，且这种改变依赖于饮食方式。
Endocrinology. 2011 Dec;152(12):4825-37. doi: 10.1210/en.2011-1447. Epub 2011 Oct 11.
5
Short-term administration of pegvisomant improves hepatic insulin sensitivity and reduces soleus muscle intramyocellular lipid content in young adults with type 1 diabetes.短期给予培维索孟可改善1型糖尿病青年患者的肝脏胰岛素敏感性，并降低比目鱼肌细胞内脂质含量。
J Clin Endocrinol Metab. 2014 Feb;99(2):639-47. doi: 10.1210/jc.2013-3264. Epub 2013 Dec 11.
6
Growth hormone signaling and action in obese versus lean human subjects.肥胖与瘦人体中生长激素的信号转导和作用。
Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E333-E344. doi: 10.1152/ajpendo.00431.2018. Epub 2018 Dec 21.
7
Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.在具有升高的内源性生长激素（GH）和胰岛素样生长因子-I（IGF-I）的雄性小鼠中，胰岛胰岛素含量和释放增加，且没有全身性胰岛素抵抗或β细胞量改变的证据。
Growth Horm IGF Res. 2015 Aug;25(4):189-95. doi: 10.1016/j.ghir.2015.04.002. Epub 2015 Apr 17.
8
The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly.培维索孟治疗对肢端肥大症患者底物代谢和胰岛素敏感性的影响。
J Clin Endocrinol Metab. 2007 May;92(5):1724-8. doi: 10.1210/jc.2006-2276. Epub 2007 Mar 6.
9
Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.生长激素缺乏的人类中生长激素与胰岛素样生长因子I对底物氧化及胰岛素敏感性影响的比较。
J Clin Invest. 1994 Sep;94(3):1126-33. doi: 10.1172/JCI117427.
10
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.抑制生长激素作用可改善肝脏胰岛素样生长因子-1缺乏小鼠的胰岛素敏感性。
J Clin Invest. 2004 Jan;113(1):96-105. doi: 10.1172/JCI17763.

引用本文的文献

1
Increased hepatic putrescine levels as a new potential factor related to the progression of metabolic dysfunction-associated steatotic liver disease.肝腐胺水平升高可能是与代谢功能障碍相关的脂肪性肝病进展的新潜在因素。
J Pathol. 2024 Sep;264(1):101-111. doi: 10.1002/path.6330. Epub 2024 Jul 18.
2
Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis.生长激素受体 (GHR)-信号对肝糖酵解、从头脂肪生成和胰岛素敏感性的直接和系统作用，与脂肪变性有关。
Metabolism. 2023 Jul;144:155589. doi: 10.1016/j.metabol.2023.155589. Epub 2023 May 13.
3
Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice.肝细胞过氧化物酶体增殖物激活受体 γ 促进雄性和雌性肥胖小鼠非酒精性脂肪性肝炎的进展。
Cell Mol Life Sci. 2023 Jan 11;80(2):39. doi: 10.1007/s00018-022-04629-z.
4
Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism.探讨生长激素调控肝细胞糖脂代谢的直接和间接作用。
Cells. 2021 Sep 24;10(10):2532. doi: 10.3390/cells10102532.
5
Rosiglitazone Requires Hepatocyte PPARγ Expression to Promote Steatosis in Male Mice With Diet-Induced Obesity.罗格列酮需要肝细胞 PPARγ 表达来促进饮食诱导肥胖雄性小鼠的脂肪变性。
Endocrinology. 2021 Nov 1;162(11). doi: 10.1210/endocr/bqab175.
6
Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms.早期营养过剩通过性别差异机制使生长激素轴对饮食诱导肥胖的影响敏感。
Sci Rep. 2020 Aug 17;10(1):13898. doi: 10.1038/s41598-020-70898-y.
7
Loss of Hepatocyte-Specific PPAR Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet.肝细胞特异性过氧化物酶体增殖物激活受体表达缺失可改善喂食蛋氨酸和胆碱缺乏饮食小鼠的脂肪性肝炎早期事件。
PPAR Res. 2020 May 1;2020:9735083. doi: 10.1155/2020/9735083. eCollection 2020.
8
Insulin signaling in the whole spectrum of GH deficiency.全谱生长激素缺乏症中的胰岛素信号传导
Arch Endocrinol Metab. 2019 Nov-Dec;63(6):582-591. doi: 10.20945/2359-3997000000188.
9
Insulin Sensitivity Is Not Decreased in Adult Patients With Hypopituitarism Without Growth Hormone Replacement.在未接受生长激素替代治疗的成年垂体功能减退患者中，胰岛素敏感性并未降低。
Front Endocrinol (Lausanne). 2019 Aug 7;10:534. doi: 10.3389/fendo.2019.00534. eCollection 2019.
10
Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice.顺式-9，反式-11-和反式-10，顺式-12-CLA 异构体对成年雄性小鼠葡萄糖和脂代谢的组织依赖性影响。
J Nutr Biochem. 2019 May;67:90-100. doi: 10.1016/j.jnutbio.2019.01.020. Epub 2019 Feb 10.

本文引用的文献

1
Insulin sensitivity in long-living Ames dwarf mice.长寿的艾姆斯侏儒小鼠的胰岛素敏感性。
Age (Dordr). 2014;36(5):9709. doi: 10.1007/s11357-014-9709-1. Epub 2014 Aug 29.
2
Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.长期而非短期的成年起病、孤立性 GH 缺乏症可导致雄性小鼠的 β 细胞功能恶化，这不能用 β 细胞质量的变化来解释。
Endocrinology. 2014 Mar;155(3):726-35. doi: 10.1210/en.2013-1825. Epub 2013 Dec 16.
3
Elevated systolic blood pressure in male GH transgenic mice is age dependent.雄性 GH 转基因小鼠的收缩压升高与年龄有关。
Endocrinology. 2014 Mar;155(3):975-86. doi: 10.1210/en.2013-1899. Epub 2013 Jan 1.
4
Lifetime congenital isolated GH deficiency does not protect from the development of diabetes.终身先天性孤立性生长激素缺乏症并不能预防糖尿病的发生。
Endocr Connect. 2013 Jun 15;2(2):112-7. doi: 10.1530/EC-13-0014. Print 2013 Jun 1.
5
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice.生长激素在脂肪组织中的作用：来自脂肪特异性生长激素受体基因敲除小鼠的启示。
Mol Endocrinol. 2013 Mar;27(3):524-35. doi: 10.1210/me.2012-1330. Epub 2013 Jan 24.
6
Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis.6050 例成年起病生长激素缺乏患者接受生长激素替代治疗前糖尿病患病率：KIMS 分析。
Eur J Endocrinol. 2013 Feb 15;168(3):297-305. doi: 10.1530/EJE-12-0807. Print 2013 Mar.
7
Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.靶向敲除小鼠骨骼肌中的 GHR 信号可预防高脂饮食引起的代谢恶化。
Diabetes. 2012 Jan;61(1):94-103. doi: 10.2337/db11-0814.
8
The interaction of hepatic lipid and glucose metabolism in liver diseases.肝脏疾病中肝脂和糖代谢的相互作用。
J Hepatol. 2012 Apr;56(4):952-64. doi: 10.1016/j.jhep.2011.08.025. Epub 2011 Dec 13.
9
Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency.成年人终身未经治疗的孤立性生长激素缺乏症的胰岛素敏感性和β细胞功能。
J Clin Endocrinol Metab. 2012 Mar;97(3):1013-9. doi: 10.1210/jc.2011-2590. Epub 2011 Dec 14.
10
Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice.对清醒、自由活动的小鼠进行高胰岛素-正常血糖钳夹实验。
J Vis Exp. 2011 Nov 16(57):3188. doi: 10.3791/3188.

选择性生长激素缺乏和内源性生长激素过多对雄性小鼠肌肉和肝脏中胰岛素介导作用的差异影响。

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

作者信息

Cordoba-Chacon Jose, Gahete Manuel D, McGuinness Owen P, Kineman Rhonda D

机构信息

Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois;

Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia, and CIBER de la Fisiopatología de la Obesidad y Nutrición, Córdoba, Spain; and.

出版信息

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.

DOI:10.1152/ajpendo.00420.2014
PMID:25269484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4233257/
Abstract

A reciprocal relationship between insulin sensitivity and glucose tolerance has been reported in some mouse models and humans with isolated changes in growth hormone (GH) production and signaling. To determine if this could be explained in part by tissue-specific changes in insulin sensitivity, hyperinsulinemic-euglycemic clamps were performed in mice with adult-onset, isolated GH deficiency and in mice with elevated endogenous GH levels due to somatotrope-specific loss of IGF-I and insulin receptors. Our results demonstrate that circulating GH levels are negatively correlated with insulin-mediated glucose uptake in muscle but positively correlated with insulin-mediated suppression of hepatic glucose production. A positive relationship was also observed between GH levels and endpoints of hepatic lipid metabolism known to be regulated by insulin. These results suggest hepatic insulin resistance could represent an early metabolic defect in GH deficiency.

摘要

在一些生长激素（GH）产生和信号传导发生孤立变化的小鼠模型和人类中，已报道胰岛素敏感性和葡萄糖耐量之间存在相互关系。为了确定这是否部分可以通过胰岛素敏感性的组织特异性变化来解释，对成年期发病、孤立性GH缺乏的小鼠以及由于生长激素细胞特异性缺失IGF-I和胰岛素受体而导致内源性GH水平升高的小鼠进行了高胰岛素-正常血糖钳夹试验。我们的结果表明，循环GH水平与肌肉中胰岛素介导的葡萄糖摄取呈负相关，但与胰岛素介导的肝葡萄糖生成抑制呈正相关。在GH水平与已知受胰岛素调节的肝脂质代谢终点之间也观察到正相关关系。这些结果表明，肝脏胰岛素抵抗可能是GH缺乏症早期的代谢缺陷。