Greijdanus-Van Der Putten S W M, Vos J H, Duvekot J R V, Paillot R, McLean R, Brokers H J, Heuvelink A E, Meertens N M, Waller A S
Tijdschr Diergeneeskd. 2014 Sep 1;139(9):24-7.
A 2.5-years-old female mongrel dog was routinely subcutaneously vaccinated. A few hours later mental dullness was noticed by the owner progressing into stupor the next day and resulting in a comatose state and death within 48 hours after vaccination. At post mortem examination, which was extended with histology and bacteriology, a necrotizing fasciitis and bacteremia caused by Streptococcus equi subsp. zooepidemicus were established. In the isolated Streptococcus strain four different superantigens were demonstrated that appeared to be able to produce exotoxins in vitro. Therefore, it is concluded that the minor skin trauma caused by vaccination enabled this strain to gain access to the subcutaneous tissue and to induce a necrotizing fasciitis. This process was complicated with a bacterial septicemia leading to death of the dog within 48 hours.
一只2.5岁的雌性杂种犬接受常规皮下疫苗接种。几小时后，主人发现其精神萎靡，第二天发展为昏迷，在接种疫苗后48小时内陷入昏迷状态并死亡。尸检时进行了组织学和细菌学检查，确诊为由马链球菌兽疫亚种引起的坏死性筋膜炎和菌血症。在分离出的链球菌菌株中，发现了四种不同的超抗原，这些超抗原在体外似乎能够产生外毒素。因此得出结论，疫苗接种造成的轻微皮肤创伤使该菌株得以进入皮下组织并引发坏死性筋膜炎。这一过程因细菌性败血症而复杂化，导致该犬在48小时内死亡。
